Beyond the Transport Function of Import Receptors: What's All the FUS about?

Cell

Departments of Biology and Chemistry, Pharmacy and Geosciences, Johannes Gutenberg-University Mainz, Johann-Joachim-Becher-Weg 7, 55128 Mainz, Germany; Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany; European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Electronic address:

Published: April 2018

Nuclear import receptors are central players in transporting protein cargoes into the nucleus. Moving beyond this role, four newly published articles describe a function in regulating supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of devastating neurodegenerative disorders.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611746PMC
http://dx.doi.org/10.1016/j.cell.2018.04.002DOI Listing

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