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Autoimmune progesterone dermatitis in the adolescent population.
Pediatr Dermatol
March 2021
Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
Background/objective: Autoimmune progesterone dermatitis (APD) is a rare autoimmune hypersensitivity reaction that occurs cyclically at the peak of endogenous progesterone production during the menstrual cycle in women. No study characterizing APD in the adolescent population is found; it appears likely to be underdiagnosed and undertreated.
Methods: A retrospective, single-center, review of all adolescent and pediatric patients (<20 years old at onset) with documented diagnosis of APD.
Efficacy of an anti-TNF-alpha agent in refractory livedoid vasculopathy: a retrospective analysis.
J Dermatolog Treat
February 2022
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Livedoid vasculopathy is a recurrent thrombo-occlusive vasculopathy of cutaneous blood vessels and its standard or first-line therapy is still controversial. Besides hypercoagulability, inflammatory factors may also play a secondary role in the pathogenesis of this disease. Monotherapy of thrombolytics cannot achieve satisfactory results because of concomitant inflammation.
View Article and Find Full Text PDFCase of autoimmune progesterone dermatitis presenting as necrotic migratory erythema successfully controlled by danazol.
J Dermatol
February 2020
Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Autoimmune progesterone dermatitis (APD) is a rare cutaneous disorder with cyclic skin eruptions during the luteal phase of the menstrual cycle. Patients can present with various clinical manifestations, including urticaria and angioedema, erythema multiforme, eczema, fixed drug eruption and centrifugal erythema annulare. In our case, however, the patient's skin lesions mimic necrotic migratory erythema (NME) which is most commonly associated with glucagonoma and rarely with liver disease, inflammatory bowel disease, malnutrition and other tumors.
View Article and Find Full Text PDFAutoimmune Progesterone Dermatitis Diagnosed by Lymphocyte Transformation Test and Progesterone Provocation Test.
Acta Dermatovenerol Croat
October 2018
Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;
Autoimmune progesterone dermatitis (APD) is rare autoimmune response to endogenous progesterone or to earlier exposure to exogenous progesterone (1). Skin lesions typically occur due to increases in progesterone during the luteal phase of the menstrual cycle (2). A-31-year-old mother of two children presented to our Department with a 5-year history of pruritic and painful erythematosus macules, papules, and patches on her neck, pectoral region, and face, which appeared 2-3 days before the onset of menses and gradually resolved 7-10 days later (Figure 1).
View Article and Find Full Text PDFDanazol-induced Stevens-Johnson syndrome in a patient with systemic lupus erythematosus.
Dermatol Online J
January 2015
Changi General Hospital, Singapore.
A patient with Stevens-Johnson syndrome related to danazol is presented.
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