The direct enantioselective chiral calcium(ii)·phosphate complex (Ca[CPA])-catalyzed conjugate addition of unprotected alkyl amines to maleimides was developed. This mild catalytic system represents a significant advance towards the general convergent asymmetric amination of α,β-unsaturated electrophiles, providing medicinally relevant chiral aminosuccinimide products in high yields and enantioselectivities. Furthermore, the catalyst can be reused directly from a previously chromatographed reaction and still maintain both high yield and selectivity.
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| http://dx.doi.org/10.1039/c7sc05205g | DOI Listing |
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