Objective: Predicting who will develop osteoarthritis, assessing how rapidly their disease will progress and monitoring early responses to treatment are key to the development of therapeutic agents able to treat this crippling disease and to their future clinical use. Statistical Shape Modelling (SSM) enables quantification of variations in multiple geometric measures describing the whole hip joint to be considered in concert. This prospective study evaluates the responsiveness of SSM to changes in hip-shape within 1 year.
Methods: Sixty-two people, mean age 67.1 yrs, were recruited. Dual-energy X-ray Absorptiometry images were taken at three timepoints (baseline, 6 and 12 months). Based on Kellgren-Lawrence grading (KLG) of their baseline images, subjects were classified into control/doubtful OA: KLG < 1 in both hips; moderate OA: KLG = 2; and severe OA: KLG ≥ 3 in their most severe hip. Morphology was quantified using SSM and changes in shape were assessed using generalised estimating equations. Standardized response means (SRMs) were calculated for the first and second 6 month periods, then the full 12 months.
Results: Disease severity ranged from KLG0-KLG4 in the 124 hips assessed at baseline. Three SSM modes (Modes 1, 3 and 4) were associated with OA severity. Across the whole cohort, SRM magnitudes ranged from 0.16 to 0.63. The greatest subgroup SRM (magnitude 0.91) was observed over 12 months in those subjects with moderate OA (KLG2).
Conclusions: We have demonstrated that SSM can capture changes in hip shape over 6 and 12 months across the entire hip joint providing a sensitive measure of hip OA progression.
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http://dx.doi.org/10.1016/j.joca.2018.04.004 | DOI Listing |
Alzheimers Dement
December 2024
Northumbria University, Newcastle, United Kingdom.
Background: Mealtimes are a fundamental part of life; eating and drinking well is vital for health well-being. People living with dementia are at increased risk of eating and drinking difficulties, and may experience difficulties at mealtimes due to the cognitive component of this condition. Such difficulties are prevalent in care homes, where people living with dementia are often dependent on carers at mealtimes.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Michigan, Ann Arbor, MI, USA.
Background: Marital status is an important but often overlooked sociodemographic factor that could shape cognitive health in late adulthood. Being married is shown to be linked to lower risk of dementia, but less is understood about underlying mechanisms contributing to this relationship, such as brain reserve (BR) and cognitive reserve (CR). Further, less is known about how living arrangement, independent of marital status, is associated with late-life cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Minnesota Duluth, Duluth, MN, USA.
Background: When designing cutting-edge technology, particularly humanoid social robots, an essential consideration is understanding how individuals naturally engage in social interactions, shaping their relationships with technology and media.
Method: In pursuit of insights into the application of natural human behavior, specifically reciprocation, in human-robot interaction, an experiment involving 72 participants, involving facial electromyography, focusing on zygomatic and corrugator muscles, served as a tool to gauge users' emotional valence during interactions. The study assessed users' willingness to reciprocate a favor and measured compliance by tracking the number of raffle tickets purchased by users at the robot's request.
Int J Clin Pediatr Dent
November 2024
Department of Pedodontics and Preventive Dentistry, Vivekanandha Dental College for Women, Namakkal, Tamil Nadu, India.
Aims And Background: Failure of the endodontic treatment might be due to various reasons like zipping, apical blockade, ledging, debris extrusion, etc. Apical debris extrusion in primary teeth is of major concern as it does not have a proper well-developed apex, that is, mature apex. This study aims to compare and evaluate the apical debris extrusion in primary molars using three different pediatric rotary file system.
View Article and Find Full Text PDFInt J Clin Pediatr Dent
November 2024
Department of Pediatric and Preventive Dentistry, Maharashtra Institute of Dental Sciences & Research (MIDSR), Latur, Maharashtra, India.
Aim: The aim of this study was to evaluate and compare the apical microleakage of zinc oxide (ZOE) eugenol and Endoflas as obturating materials using different root canal irrigants in primary teeth.
Materials And Methods: A total of 80 extracted primary anterior teeth were divided randomly into four groups with different irrigants and obturating materials used. Group I [ZOE + sodium hypochlorite (NaOCl)], group II [ZOE + NaOCI + ethylenediaminetetraacetic acid (EDTA)], group III (Endoflas FS + NaOCI), group IV (Endoflas FS + NaOCI + EDTA).
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