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4-Substituted carbamazepine derivatives: Conformational analysis and sodium channel-blocking properties. | LitMetric
The physicochemical properties of 4-substituted carbamazepine derivatives were investigated. It was elucidated that the 4-substitution is not effective in reducing the rotations (E/Z) about the N-C1' axes around the outer carbamoyl moiety. However, the atropisomers were isolated with high stereochemical stability, meaning that the 4-substitution reduced the butterfly motion of the tricyclic ring system efficiently. The Cl/CH-substituted carbamazepine derivatives showed greater inhibitory effects on hNa1.2 channel currents compared with carbamazepine, although no difference in the activity between enantiomers was observed.
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