AI Article Synopsis
- Carbapenemase-producing Enterobacteriaceae (CPE) pose a significant public health threat globally, with limited reports in Mexico, particularly among children.
- A study at a pediatric hospital in Mexico City documented seven cases of CPE, identifying various strains of E. coli and Klebsiella, with most patients suffering from underlying health issues and half of them succumbing to infections.
- This research is notable for being the first to report specific CPE strains, including E. coli ST131-O25b with NDM-1 and K. oxytoca with OXA-48, in the Mexican pediatric population.
Article Abstract
Background: Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in the pediatric population. Here, we describe the clinical, epidemiological, and molecular characteristics of seven consecutive cases in a third-level pediatric hospital in Mexico City over a four-month period during 2016.
Results: The Enterobacteriaceae identified were three Escherichia coli strains (producing OXA-232, NDM-1 and KPC-2), two Klebsiella pneumoniae strains (producing KPC-2 and NDM-1), one Klebsiella oxytoca strain producing OXA-48 and one Enterobacter cloacae strain producing NDM-1. The majority of patients had underlying disesases, three were immunocompromised, and three had infections involved the skin and soft tissues. Half patients died as a result of CPE infection.
Conclusions: This study represents the first report of E. coli ST131-O25b clone producing NDM-1 in Latin America. In addition, this study is the first finding of K. oxytoca producing OXA-48 and E. coli producing OXA-232 in Mexican pediatric patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907697 | PMC |
| http://dx.doi.org/10.1186/s12866-018-1166-z | DOI Listing |
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