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Diets containing phytobiotics, l-arginine, vitamin E and captopril modulate ascites syndrome-related genes expression in broiler chickens exposed to low ambient temperature.
Vet Med Sci
September 2024
Department of Animal Sciences, College of Agricultural Sciences and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
Background: Our hypothesis centred on the potential to mitigate ascites outbreaks in birds exposed to cold stress by inhibiting pulmonary artery contraction through dietary intervention.
Objective: This study aimed to evaluate the effect of natural and synthetic medications on growth performance, ascites-related parameters and the expression of ascites-related genes in the lung tissue of broiler chickens under low ambient temperature.
Methods: We randomly assigned 450 one-day-old male Ross 308 chicks to six dietary treatments across five replicate pens, each containing 15 chicks.
Aerosol Delivery of a Novel Recombinant Modified Superoxide Dismutase Protein Reduces Oxidant Injury and Attenuates Induced Lung Injury in Rats.
J Aerosol Med Pulm Drug Deliv
October 2023
SFI Centre for Medical Devices (CÚRAM), University of Galway, Galway, Ireland.
Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory failure syndrome with diverse etiologies characterized by increased permeability of alveolar-capillary membranes, pulmonary edema, and acute onset hypoxemia. During the ARDS acute phase, neutrophil infiltration into the alveolar space results in uncontrolled release of reactive oxygen species (ROS) and proteases, overwhelming antioxidant defenses and causing alveolar epithelial and lung endothelial injury. To investigate the therapeutic potential of a novel recombinant human Cu-Zn-superoxide dismutase (SOD) fusion protein in protecting against ROS injury and for aerosolized SOD delivery to treat induced ARDS.
View Article and Find Full Text PDFEvaluation of Genetic Polymorphisms of the Antioxidant Enzymes and Biomarkers of Oxidative Stress in Preterm Neonates With Respiratory Distress Syndrome Receiving External Surfactant.
Biomark Insights
November 2022
Department of Pediatrics, RCSI-MUB, Manama, Kingdom of Bahrain.
Background: Preterm neonates, particularly extremely preterm, are susceptible to respiratory distress syndrome (RDS) due to surfactant deficiency. Single nucleotide polymorphisms (SNPs) in the antioxidant enzymes influence the balance between antioxidant and oxidative stress molecules.
Objectives: To ascertain the role of SNPs of antioxidant enzymes and oxidative stress biomarkers in preterm neonates with RDS.
Stress-Induced Premature Senescence Related to Oxidative Stress in the Developmental Programming of Nonalcoholic Fatty Liver Disease in a Rat Model of Intrauterine Growth Restriction.
Antioxidants (Basel)
August 2022
Department of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.
Article Synopsis
- - Metabolic syndrome (MetS) is a combination of health issues like obesity, insulin resistance, high blood pressure, and liver disease, with individuals born after intrauterine growth restriction (IUGR) facing higher risks of these conditions later in life.
- - A study involving rats showed that male offspring with IUGR (induced by a low-protein diet during pregnancy) had increased visceral fat, glucose intolerance, and liver damage compared to control males, while no significant differences were noted in female offspring.
- - The livers of IUGR males exhibited signs of stress-induced premature senescence and oxidative stress, pointing to impaired liver function and structure, suggesting the need for targeted therapies to mitigate the negative impacts of IUG
Polymorphism of Transferrin Gene Impacts the Mediating Effects of Psychotic Symptoms on the Relationship between Oxidative Stress and Cognition in Patients with Chronic Schizophrenia.
Antioxidants (Basel)
January 2022
CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, China.
A series of studies indicated that iron distribution that partly derives from transferrin-bound iron in the peripheral nervous system in the brain may act in processes such as myelination and brain development. However, the relationship between schizophrenia, its psychotic symptoms, and the transferrin (TF) gene has not been systematically explored. Our study aimed to investigate how a particular polymorphism of the transferrin gene, rs3811655, affects the superoxide dismutase (SOD), malondialdehyde (MDA), psychotic symptoms, cognition, or the mediation model between antioxidant enzymes and cognition via symptoms.
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