AI Article Synopsis
- Injury to the central nervous system (CNS), particularly from traumatic brain injury (TBI) and stroke, affects the structure and function of the brain, with many underlying mechanisms still unclear.
- The body's immune response can worsen brain damage after the initial injury, leading to secondary complications that present opportunities for treatment.
- This paper focuses on how inflammation contributes to cell death in CNS injuries and explores the spleen's role in the body's overall inflammatory response following such injuries.
Article Abstract
Injury to the central nervous system (CNS) is common, and though it has been well studied, many aspects of traumatic brain injury (TBI) and stroke are poorly understood. TBI and stroke are two pathologic events that can cause severe, immediate impact to the neurostructure and function of the CNS, which has been recognized recently to be exacerbated by the body's own immune response. Although the brain damage induced by the initial trauma is most likely unsalvageable, the secondary immunologic deterioration of neural tissue gives ample opportunity for therapeutic strategists seeking to mitigate TBI's secondary detrimental effects. The purpose of this paper is to highlight the cell death mechanisms associated with CNS injury with special emphasis on inflammation. The authors discuss sources of inflammation, and introduce the role of the spleen in the systemic response to inflammation after CNS injury.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901724 | PMC |
| http://dx.doi.org/10.20517/2347-8659.2017.07 | DOI Listing |
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