Purpose: To compare the differential diagnostic values of F-Alfatide II PET/CT between tuberculosis and lung cancer patients and in patients with sarcoidosis and common inflammation.
Methods: Nine inflammation patients (4 tuberculosis, 3 sarcoidosis, and 2 common inflammation) and 11 lung cancer patients were included in this study. All patients underwent F-FDG and F-Alfatide II PET/CT within 2 weeks, followed by biopsy and surgery. The maximized standard uptake value (SUVmax) and the mean standard uptake value (SUVmean) were evaluated.
Results: The active tuberculosis lesions showed a high accumulation of F-FDG, but varying degrees of accumulation of F-Alfatide II, including negative results. The SUVmax of F-Alfatide II in malignant lesions was significantly higher than that in tuberculosis (4.08 ± 1.51 versus 2.63 ± 1.34, = 0.0078). Three patients with sarcoidosis showed negative results in F-Alfatide II PET/CT.
Conclusions: The expression of is much lower in tuberculosis as compared to that in lung cancer, and accumulation of F-Alfatide II varied even in lesions of the same patient. The negative results of sarcoidosis patients led to the speculation that was not expressed in those lesions.
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| http://dx.doi.org/10.1155/2018/8194678 | DOI Listing |
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