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Conventional suspension delivery versus tattooing pen-assisted suspension delivery in non-cultured epidermal cell suspension procedure for vitiligo: A randomized controlled trial.
Pigment Cell Melanoma Res
November 2024
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- Non-cultured epidermal suspension (NCES) is a popular surgical treatment for stable vitiligo, and the method of delivering the suspension significantly affects the results.
- A study compared two delivery methods: conventional suspension delivery after manual dermabrasion (CSMD) and tattooing pen-assisted suspension delivery (TPSD) in 36 patients, examining repigmentation success over 24 weeks.
- Results showed that CSMD achieved better repigmentation in 86.1% of cases compared to 61.1% for TPSD, and while CSMD had more complications, TPSD had no perilesional halo effects, suggesting room for improvement in tattooing pen techniques.
Noncultured Trypsinized Epidermal Cell Suspension Transplantation After Cryoblebbling Versus Noncultured Nontrypsinized Epidermal Cell Graft Homogenized With Plasma Gel After Dermabrasion for Stable Vitiligo.
Dermatol Surg
September 2024
All authors are affiliated with the Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Article Synopsis
- Vitiligo treatment is difficult, especially in stable cases that need surgical options; researchers modified noncultured epidermal cell suspension to improve results.
- The study compared two methods for stable vitiligo: one using trypsinized cells with cryoblebbling, and the other with nontrypsinized cells mixed with plasma gel and dermabrasion.
- Results showed that the plasma gel method led to faster healing and repigmentation, fewer complications, and was easier and cheaper compared to the cryobleb method.
Treatment of Post-Burn Leucoderma With Superficial Dermabrasion Followed by Suction Blister Epidermal Grafting: A Clinical Prospective Study.
Ann Burns Fire Disasters
June 2023
Plastic, Reconstructive Surgery and Burns Department, Tanta Faculty of Medicine, Tanta, Egypt.
Article Synopsis
- Post-burn leucoderma presents treatment challenges due to both textural changes and hypopigmentation, which need to be addressed simultaneously.
- This study examined the effectiveness of superficial dermabrasion combined with suction blister epidermal grafting (SBEG) on 20 patients, focusing on the surgical process, repigmentation, and complications.
- Results showed varying levels of treatment success, with 75% of patients satisfied with the outcomes, indicating that the combined approach is a simple and cost-effective option for managing localized post-burn leucoderma.
Melanocyte transplantation to skin prepared by controlled PUVA-induced sunburn-like blistering for vitiligo treatment - A pilot clinical trial.
J Formos Med Assoc
August 2024
Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan; Center for Frontier Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
Vitiligo is a common acquired disease of pigment loss. In lesions recalcitrant to non-invasive treatment, transplantation of cultured autologous melanocytes is an emerging choice. Conventionally, the recipient site is often prepared by laser-mediated or mechanical dermabrasion.
View Article and Find Full Text PDFDermabrasion Versus Microneedling in Transplantation of Autologous Noncultured Melanocyte-Keratinocyte Cell Suspension in Patients With Vitiligo.
Dermatol Surg
May 2023
All authors are affiliated with the Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Background: Autologous noncultured melanocyte-keratinocyte transplantation is one of the procedures used to treat stable vitiligo with varying reported results. Recipient site preparation is one of the variables that could affect repigmentation outcomes.
Objective: To assess the effectiveness of transplanting autologous melanocyte-keratinocyte suspension in patients with stable vitiligo and to compare recipient site preparation using dermabrasion versus microneedling.
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