Introduction: The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention.
Methods: We included 48 ALS patients randomized in 2 groups: G1 ( = 24), exercise intensity leveled by CPET; G2 ( = 24), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission (1) and 6 months later (2). We registered oxygen uptake, carbon dioxide output, and ventilation at anaerobic threshold and at peak effort. Primary outcome was functional change. We used parametric statistics for comparisons and multiple regression analyses to identify independent predictors of functional decline.
Results: At 1 both groups were identical, except for higher FVC in G1 ( = 0.02). At 2, ALSFRS-R was higher ( = 0.035) in G1. Gas exchange variables at 2 did not change in G1 but had significant differences in G2 ( < 0.05). Multiregression analyses showed the Spinal ALSFRS-R slope and Intervention group ( < 0.001) as significant predictors of ALSFRS-R at 2.
Conclusion: Aerobic exercise defined by CPET is feasible and can improve functional outcome in ALS. This trial is registered with Clinical trials.gov ID: NCT03326622.
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http://dx.doi.org/10.1155/2018/8218697 | DOI Listing |
Comput Methods Biomech Biomed Engin
January 2025
Department of Mathematics, National Institute of Technology Uttarakhand, Srinagar, India.
As humans age, they experience deformity and a decrease in their bone strength, such brittleness in the bones ultimately lead to bone fracture. Magnetic field exposure combined with physical exercise may be useful in mitigating age-related bone loss by improving the canalicular fluid motion within the bone's lacuno-canalicular system (LCS). Nevertheless, an adequate amount of fluid induced shear stress is necessary for the bone mechano-transduction and solute transport in the case of brittle bone diseases.
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January 2025
Nursing Department, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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January 2025
Department of Preventive Medicine, University of Mississippi Medical Center, Jackson, MS, USA (OA, AG, CC, JRM, JB, BDW).
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Oxford University Hospitals NHS Trust, Oxford, United Kingdom.
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January 2025
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