The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in and on this human disease-associated variant lead us to propose a new "switch-of-function" model.
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| http://dx.doi.org/10.1126/scisignal.aat0936 | DOI Listing |
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