Background: Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity and subcellular localization of Tax is strongly influenced by posttranslational modifications, among which ubiquitylation and SUMOylation have been identified as key regulators of the nuclear/cytoplasmic shuttling of Tax, as well as its ability to activate NF-κB signaling.
Results: Adding to the complex posttranslational modification landscape of Tax, we here demonstrate that Tax also interacts with the ubiquitin-related modifier 1 (Urm1). Conjugation of Urm1 to Tax results in a redistribution of Tax to the cytoplasm and major increase in the transcription of the NF-ĸB targets Rantes and interleukin-6. Utilizing a tax-transgenic Drosophila model, we show that the Urm1-dependent subcellular targeting of Tax is evolutionary conserved, and that the presence of Urm1 is strongly correlated with the transcriptional output of Diptericin, an antimicrobial peptide and established downstream target of NF-κB in flies.
Conclusions: These data put forward Urm1 as a novel Tax modifier that modulates its oncogenic activity and hence represents a potential novel target for developing new strategies for treating ATL.
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http://dx.doi.org/10.1186/s12977-018-0415-4 | DOI Listing |
Ambio
December 2024
Department of Building Engineering, Energy Systems and Sustainability Science, University of Gävle, Kungsbärcksvägen 47, SE-801 76, Gävle, Sweden.
This study aims to expand the understanding of public acceptance of carbon taxes by exploring the role of habits. Habits play a pivotal role in guiding our behaviors and reasoning and can even influence our self perception and identity but remain an underexplored variable in relation to public policy acceptance. We employed a large scale (N > 5200) national survey to measure public acceptance of higher carbon taxation in Sweden, also capturing car driving habits, car usage, and other relevant variables.
View Article and Find Full Text PDFJ Clin Periodontol
December 2024
National Dental Research Institute Singapore, National Dental Centre Singapore, Singapore, Singapore.
Aim: To estimate the causal effects of smoking and cessation on tooth loss using instrumental variable (IV) analysis.
Material And Methods: Data from the Behavioural Risk Factor Surveillance System (BRFSS), conducted from 1995 to 2006, 2008, 2010, and 2012 in 50 U.S.
Anesth Analg
December 2024
West Virginia University, Morgantown, West Viriginia.
J Pediatr Gastroenterol Nutr
December 2024
Department of Pediatrics, Division of Pediatric Gastroenterology, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Health Econ Rev
December 2024
Tabriz Health Service Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Given the significant impact of the COVID-19 pandemic, it is imperative to examine the economic response policies implemented by governments. This study aims to review evidence from the Middle East and North Africa (MENA) region, including Iran, on COVID-19 economic response policies designed to protect households, vulnerable groups, and businesses.
Methods: Utilizing Arksey and O'Malley's scoping review methodology, electronic search engines and databases were systematically searched to identify published studies within the timeframe of December 31, 2019, to 2022.
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