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Cognitive decline and neuroinflammation in a mouse model of obesity: An accelerating role of ageing.
Brain Behav Immun
December 2024
Department of Geriatrics, University Medical Center Goettingen, Robert-Koch-Str. 42, 37075 Goettingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, 37075 Göttingen, Germany. Electronic address:
Obesity, a pandemic, worldwide afflicts almost one billion people. Obesity and ageing share several pathological pathways leading to neurological disorders. However, due to a lack of suitable animal models, the long-term effects of obesity on age-related disorders- cognitive impairment and dementia have not yet been thoroughly investigated.
View Article and Find Full Text PDFEvaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel.
Ticks Tick Borne Dis
December 2024
Krankenhaus Nordwest, Frankfurt, Germany.
Categorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with diverse expertise in TBEV infection. Consensus was sought using the Delphi technique, which consisted of 2 web-based survey questionnaires and a final, virtual, consensus-building exercise.
View Article and Find Full Text PDFHEMATOLOGY AND BIOCHEMICAL REFERENCE INTERVALS AND SEROPREVALENCE OF HEMORRHAGIC DISEASES FOR FREE-RANGING MULE DEER () IN WEST TEXAS.
J Zoo Wildl Med
December 2024
Texas Parks and Wildlife Department, Austin, Texas, 78744 USA.
Wildlife species are routinely captured for translocation, general health monitoring, and research-based pursuits to guide wildlife management. Mule deer () were captured for various research projects and management actions in the Trans-Pecos and Panhandle regions of Texas from 2015 to 2019. The objective of this study was to develop hematologic and biochemical parameters for free-ranging mule deer in Texas and to develop a health monitoring system for current and future mule deer population management.
View Article and Find Full Text PDFSerological proteomic profiling uncovered CDK5RAP2 as a novel marker in benign prostatic hyperplasia.
Clin Biochem
December 2024
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. Electronic address:
Background: Benign prostatic hyperplasia (BPH) affects approximately half of men over the age of 50. Early detection and timely treatment facilitate disease intervention and achieve a better clinical outcome. However, current clinical methods, such as prostate specific antigen (PSA), lack the sensitivity to accurately distinguish between BPH and prostate cancer (PCa).
View Article and Find Full Text PDFAdvances in the diagnostic techniques of African swine fever.
Virology
December 2024
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
African swine fever (ASF) is a highly contagious disease of pigs caused by African swine fever virus, which poses a huge threat to the global swine industry and is therefore listed as a notifiable disease by the World Organization for Animal Health. Due to the global lack of safe and efficacious vaccines and therapeutic drugs, early diagnosis of cases, whether on-site or laboratory, are crucial for the prevention and control of ASF. Therefore, rapid and reliable diagnosis and detection have become the main means to combat ASF.
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