Study Design: A retrospective study of consecutive patients undergoing surgery for adult spinal deformity (ASD).
Objective: The aim of this study was to classify postoperative ASD patients by sagittal compensation and characterize the features of each group.
Summary Of Background Data: Sagittal compensatory mechanisms to keep the erect position would function in not only nonoperative ASD patients but also in postoperative patients. However, details of sagittal compensatory mechanisms after surgery have been unclear, because the majority of previous studies examined the compensatory mechanisms in nonoperative patients.
Methods: A total of 73 postoperative ASD patients were recruited. Spinopelvic parameters and Oswestry Disability Index (ODI) were measured before surgery, at 1-month and 2-year follow-up. The changes in parameters (Δ) between postoperative 1-month and 2-year were also evaluated. Cluster analysis based on pelvic tilt (PT) and sagittal vertical axis (SVA) at 2-year follow-up was performed, and then the parameters were compared among clusters.
Results: Cluster analysis identified three clusters: the physiological group (n = 38, PT = 19.6°, SVA = 17.2 mm), the compensated group (n = 23, PT = 34.3°, SVA = 45.6 mm), and the decompensated group (n = 12, PT = 36.6°, SVA = 118.8 mm). Comparisons of the parameters among the groups showed that the physiological group had smaller pelvic incidence minus lumbar lordosis (PI-LL) and better ODI. The compensated group had significantly larger Δ thoracic kyphosis (TK), Δ proximal junctional angle (PJA), and ΔPT than the physiological group. The decompensated group had significantly higher PI and higher age.
Conclusion: Three groups were defined in terms of postoperative compensatory mechanisms. Patients in the physiological group had little postoperative alignment change and good ODI value. The compensated group had pelvic retroversion to keep SVA in the physiological range, but the compensation in the thoracic spine was unlikely to work. High PI and advanced age were characteristics of the decompensated group.
Level Of Evidence: 4.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/BRS.0000000000002693 | DOI Listing |
Acta Bioeng Biomech
September 2024
Faculty of Sports Science, Ningbo University, Ningbo, China.
: Asymptomatic patellar tendon abnormality (APTA) is considered a precursor to patellar tendinopathy (PT), but its pathogenesis remains unclear, especially regarding changes in muscle coordination. Therefore, it is essential to explore the muscle synergy patterns in individuals with APTA. This study recorded sEMG data during stop-jump tasks in 8 APTA and 8 healthy amateur male basketball players in a simulated basketball game.
View Article and Find Full Text PDFTau pathology in the locus coeruleus (LC) is associated with several neurodegenerative conditions including Alzheimer's disease and frontotemporal dementia. Phosphorylated tau accumulates in the LC and results in inflammation, synaptic loss, and eventually cell death as the disease progresses. Loss of LC neurons and noradrenergic innervation is thought to contribute to the symptoms of cognitive decline later in disease.
View Article and Find Full Text PDFHandb Clin Neurol
January 2025
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Sleep Medicine Centre, Neurology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Obstructive sleep apnea syndrome (OSAS) significantly affects the sleep-wake circadian rhythm through intermittent hypoxia and chronic sleep fragmentation. OSAS patients often experience excessive daytime sleepiness, frequent awakenings, and sleep fragmentation, leading to a disrupted circadian rhythm and altered sleep-wake cycle. These disruptions may exacerbate OSAS symptoms and contribute to neurodegenerative processes, particularly through the modulation of clock gene expression such as CLOCK, BMAL1, and PER.
View Article and Find Full Text PDFJ Affect Disord
January 2025
Department of Psychology, University of Turin, Turin, Italy. Electronic address:
Dysfunctional parenting (DP) is a factor of vulnerability and a predictive risk factor for psychopathology. Although previous research has shown specific functional and structural brain alterations, the neural basis of DP remains understudied. We therefore investigated EEG functional connectivity changes within the Salience Network before and after the exposure to attachment-related stimuli in individuals with high and low perceived DP.
View Article and Find Full Text PDFNeuropharmacology
January 2025
Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA-Plataforma BIONAND), 29590 Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain. Electronic address:
Lysophosphatidic acid (LPA) and the endocannabinoid system (ECS) are critical lipid signaling pathways involved in emotional regulation and behavior. Despite their interconnected roles and shared metabolic pathways, the specific contributions of LPA signaling through the LPA receptor to stress-related disorders remain poorly understood. This study investigates the effects of LPA receptor deficiency on emotional behavior and neurotransmitter-related gene expression, with a focus on sex-specific differences, using maLPA-null mice of both sexes.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!