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| http://dx.doi.org/10.11604/pamj.2018.29.16.9649 | DOI Listing |
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Pregnane C21-Steroids with Anti-inflammatory Activity from the Roots of Cynanchum bungei.
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Guangdong Medical University School of Pharmacy, School of Pharmacy, Xincheng Road, 523808, Dongguan, CHINA.
Five pregnane C21-steroids, including three 5,6-epoxy steroids (1-3) and two 8,14-seco-steroids (4 and 5), were isolated from the acid hydrolysate of Cynanchum bungei roots. Cynbungenins L-O (1-4) are previously undescribed compounds. Compound 3 with a 5a,6a-epoxy group represents the first example found in the Cynanchum plants.
View Article and Find Full Text PDFAnti-inflammatory and anti-oxidative effect of pasterurised yoghurt in indomethacin induced gastric ulceration in male Wistar rats.
Heliyon
December 2024
Department of Physiology, University of Medical Sciences, Ondo City, Ondo State, Nigeria.
Background: Yoghurt, a fermented dairy product consumed by diverse cultures for centuries, has garnered significant attention from the scientific community due to its potential health benefits and remarkable versatility. This study investigated the anti-inflammatory and anti-oxidative effects of pre-treatment with pasteurized yoghurt in indomethacin induced gastric ulceration.
Method: Thirty male Wistar rats were randomly assigned into five groups.
Cinnamic acid lowers blood pressure and reverses vascular endothelial dysfunction in rats.
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Cardiovascular Research Group, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, University Road, Abbottabad-22060, KP, Pakistan.
Cinnamic acid (CA) possesses important cardiovascular effects such as cardioprotective, antiatherogenic, antihyperlipidemic and antioxidant, which predicts its potential role in the treatment of hypertension. The study was executed to investigate the antihypertensive potential of CA in Sprague Dawley (SD) rats followed by evaluation in diverse vascular preparations. Invasive blood pressure monitoring technique was used in normotensive and hypertensive rats, under anesthesia.
View Article and Find Full Text PDFIndomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells.
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Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Istanbul, Turkiye.
Glioblastoma, with a low survival rate, is an aggressive and difficult-to-treat lethal type of brain cancer. Indomethacin (IND), a non-steroidal anti-inflammatory drug, has antitumoral activity in many cancers, including gliomas. However, its poor aqueous solubility is a critical issue.
View Article and Find Full Text PDFIn Vivo Evidence for the Preventive Role of Vaccinium macrocarpon Aiton in Indomethacin-Induced Gastric Ulcer: Focusing on Antioxidant, Anti-Inflammatory and Anti-Apoptotic Mechanisms.
Vet Med Sci
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Department of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
The present study aimed to unveil the gastroprotective potential of Vaccinium macrocarpon (VM) extract and its mechanism of action against indomethacin (INDO)-induced gastric ulcers in rats. To achieve this goal, rats were pretreated with either omeprazole (20 mg/kg) or VM (100 mg/kg) orally for 14 consecutive days. Gastric tissue samples were collected and various parameters were evaluated to understand the mechanism of VM's action, including the levels of superoxide dismutase, malondialdehyde, glutathione, CAT and transforming growth factor beta (TGF-β), as well as the mRNA expression levels of tumour necrosis factor alpha, interleukin 1 beta, nuclear factor kappa B (NF-κB) and inhibitor kappa B (IκB).
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