AI Article Synopsis
- - The study aimed to evaluate how curcumin combined with a specific polymer (PBLG-PEG-PBLG) can help treat diabetic cardiomyopathy by influencing the calcium-sensing receptor (CaSR) and cystathionine-γ-lyase (CSE) pathways.
- - Diabetic rats were given either curcumin or the curcumin/polymer complex for 8 weeks, after which researchers analyzed blood and heart tissue to measure hydrogen sulfide and calcium levels, along with various protein expressions.
- - Results showed that both treatments improved heart tissue damage and increased important biomolecules compared to untreated diabetic rats, with the polymer complex significantly enhancing curcumin's effects.
Article Abstract
Background: The objective of this study was to survey the therapeutic function of curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect of calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (HS).
Methods: Diabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks. The blood and myocardiums were collected, the level of serum HS was observed, and the [Ca] content was measured in myocardial cells, and hematoxylin-eosin, CaSR, CSE, and calmodulin (CaM) expression were detected.
Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased HS and [Ca] levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.
Conclusion: PBLG-PEG-PBLG could improve water-solubility and bioactivity of curcumin and curcumin/PBLG-PEG-PBLG significantly alleviated diabetic cardiomyopathy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892954 | PMC |
| http://dx.doi.org/10.2147/IJN.S153763 | DOI Listing |
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