AI Article Synopsis
- Maintaining cellular identity, especially in stem cells, requires constant adjustment to environmental changes to preserve their ability to differentiate.
- Mitochondria play a significant role in regulating cellular responses by controlling energy metabolism, redox states, calcium balance, and cell death, acting as a link between environmental signals and epigenetic identity.
- Understanding the role of mitochondria in the maintenance and loss of stemness, particularly in pluripotency, is crucial for advancing stem cell research and developing better medical applications.
Article Abstract
The maintenance of cellular identity requires continuous adaptation to environmental changes. This process is particularly critical for stem cells, which need to preserve their differentiation potential over time. Among the mechanisms responsible for regulating cellular homeostatic responses, mitochondria are emerging as key players. Given their dynamic and multifaceted role in energy metabolism, redox, and calcium balance, as well as cell death, mitochondria appear at the interface between environmental cues and the control of epigenetic identity. In this review, we describe how mitochondria have been implicated in the processes of acquisition and loss of stemness, with a specific focus on pluripotency. Dissecting the biological functions of mitochondria in stem cell homeostasis and differentiation will provide essential knowledge to understand the dynamics of cell fate modulation, and to establish improved stem cell-based medical applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934764 | PMC |
| http://dx.doi.org/10.15252/embr.201745432 | DOI Listing |
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