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Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases.
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Division of Dermatology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms are severe cutaneous adverse reactions to drugs that are generally considered distinct entities. In addition to identifying the offending medication, distinguishing between these diagnoses is important, as they have differing treatment regimens and prognoses. Distinction between severe cutaneous adverse reactions, particularly in the early stages of disease, can be difficult, and overlapping conditions have been reported in the literature.
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Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a CD30+ lymphoproliferative disorder with generally favorable outcomes and infrequent extracutaneous spread, usually limited to local lymph nodes. However, there may be extensive histologic overlap with more aggressive CD30+ lymphomas, such as large cell transformation of mycosis fungoides or secondary skin involvement by anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma. Definitive diagnosis relies on clinicopathologic correlation.
View Article and Find Full Text PDFInvolvement of macromolecules in 3D printing for wound healing management: A narrative review.
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Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:
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View Article and Find Full Text PDFToxic Epidermal Necrolysis Superimposed on Severe Drug Rash With Eosinophilia and Systemic Symptoms Complicated by Fatal Hemophagocytic Lymphohistiocytosis: A Case Report.
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Internal Medicine, Icahn School of Medicine at Mount Sinai/NYC Health and Hospitals/Queens Hospital Center, New York, USA.
Article Synopsis
- DRESS is a severe skin reaction that includes symptoms like skin rash, fever, and organ involvement, while TEN is an even more severe condition causing skin necrosis and detachment.
- Hemophagocytic lymphohistiocytosis (HLH) is an extreme immune response linked to severe skin reactions like DRESS.
- A case is presented where a severe DRESS reaction occurred from allopurinol use and overlapped with TEN, possibly triggered by vancomycin for sepsis, ultimately leading to a fatal HLH situation.
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