Background: It is assumed that high pore densities in flow diverters (FDs) are beneficial for intracranial aneurysm (IA) healing. However, various animal studies are not conclusive on the issue, suggesting that other factors are in play. One important factor might be wall apposition.

Objective: To (1) determine the relationship between FD pore density and aneurysm occlusion, and (2) determine the relationship between FD wall apposition and aneurysm occlusion.

Methods: Saccular aneurysms were microsurgically created in the aorta of 36 Wistar rats. Twelve rats received a low pore density FD (10 pores/mm2), 12 rats received a high pore density FD (23 pores/mm2), and the remaining 12 rats served as a control group. Six animals from each group were sacrificed 1 and 3 mo after surgery. We determined aneurysm occlusion, the number of struts not in contact with the aorta wall, and the average distance from malapposed struts to aorta wall through histology.

Results: No significant differences were found in aneurysm occlusion between the low pore density and high pore density groups (P > .05) after 1 and 3 mo of follow-up. The average number of malapposed struts was lower for the occluded aneurysm group (4.4 ± 1.9) compared to the nonoccluded aneurysm group (7.7 ± 2.6, P < .01). The average distance between malapposed struts and parent artery wall was lower for the occluded aneurysm group (33.9 μm ± 11.5 μm) than for the nonoccluded aneurysm group (48.7 μm ± 18.8 μm, P < .05).

Conclusion: Wall apposition is more important than pore density for aneurysm occlusion.

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuros/nyy092DOI Listing

Publication Analysis

Top Keywords

pore density
20
high pore
12
aneurysm occlusion
12
wall apposition
8
flow diverters
8
determine relationship
8
rats received
8
low pore
8
density pores/mm2
8
aorta wall
8

Similar Publications

We developed a unique water droplet templating method to fabricate polymer films with three-dimensionally ordered porous structures. This technique is based on a polymer/solvent/HO ternary system, and the key is to choose a volatile and hydrophobic solvent that is slightly miscible with HO. With the fast evaporation of the solvent, water droplets separate from the casting solution and condense from the air to act as pore templates inside the film and on the surface, respectively.

View Article and Find Full Text PDF

The shift from outcrossing to predominantly selfing is one of the most common transitions in plant evolution. This evolutionary shift has received considerable attention from biologists; however, this work has almost exclusively been focused on animal-pollinated systems. Despite the seminal ecological and economic importance of wind-pollinated species, the mechanisms controlling the degree of outcrossing in wind-pollinated taxa remain poorly understood.

View Article and Find Full Text PDF

Pore formation mechanism and size regulation study of atmospheric dried cellulose nanofiber aerogel templated by emulsions.

Int J Biol Macromol

January 2025

College of Textile Science & Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China. Electronic address:

Atmospheric pressure drying (APD) method holds great promise in the large-scale production of aerogels without specialized equipment and critical conditions. However, atmospheric-dried cellulose- based aerogels are challenged by the collapse of the pore walls induced by the capillary force that arises during solvent evaporation. This study prepared an atmospheric dried cellulose nanofiber (CNF) aerogel with a low shrinkage rate (17.

View Article and Find Full Text PDF

Intra-Mesopore Immunoassay Based on Core-Shell Structured Magnetic Hierarchically Porous ZIFs.

ACS Sens

January 2025

Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

It is crucial yet challenging to sensitively quantify low-abundance biomarkers in blood for early screening and diagnosis of various diseases. Herein, an analytical model of intra-mesopore immunoassay (IMIA) was proposed, which was competent to examine various biomarkers at the femtomolar level. The success is rooted in the design of an innovative superparamagnetic core-shell structure with FeO nanoparticles (NPs) at the core and hierarchically porous zeolitic imidazolate frameworks as a shell (FeO@HPZIF-8), achieved through a soft-template directed self-assembly coupled with confinement growth mechanism.

View Article and Find Full Text PDF

Background: Intradermal injection of CPM-HA20G, a low-viscoelasticity hyaluronic acid (HA) dermal filler with glycerol, has been shown to be effective for facial rejuvenation in Caucasians, but research in Asians is limited.

Aims: This study aimed to evaluate the effectiveness and safety of CPM-HA20G in enhancing facial skin quality in Korean women using a protocol developed by local aesthetic experts.

Patients/methods: In this 24-week prospective, single-arm, open-label study, 20 women received CPM-HA20G injections in the immediate subdermal layer on the anterior cheek (1 mL per side; total 2 mL) in three sessions every 4 weeks.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!