AI Article Synopsis
- Prostate adenocarcinoma-III (PA-III) cells caused both bone loss (osteolytic changes) and new bone formation (osteoplastic changes) in L-W rats' scapulae.
- The drug dichloromethylene diphosphonate (Cl2MDP) effectively halted the bone loss but couldn't stop the new bone formation once it started.
- Ionizing radiation was able to interrupt the new bone formation, and using both Cl2MDP and x-rays on the affected bones stopped both processes from worsening.
Article Abstract
Prostate adenocarcinoma-III (PA-III) cells deposited over the scapula of Lobund-Wistar (L-W) rats induced osteolytic and osteoplastic changes in that bone. The osteolytic process was prevented and interrupted by administrations of dichloromethylene diphosphonate (Cl2MDP); but the osteoplastic process, once initiated, continued. The latter process was interrupted by ionizing radiation. Treatments of PA-III-affected bones with Cl2MDP and x-rays immobilized both osteolytic and osteoplastic processes.
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| http://dx.doi.org/10.1002/1097-0142(19880515)61:10<2027::aid-cncr2820611017>3.0.co;2-j | DOI Listing |
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