A simple and rapid method for F radiolabelling of [GaF (BnMe -tacn)] by F/ F isotopic exchange is described. The use of MeCN/H O or EtOH/H O (75:25) and aqueous [ F]F (up to 200 MBq) with heating (80 °C, 10 min) gave 66±4 % F incorporation at a concentration of 268 nm, and 37±5 % F incorporation at even lower concentration (27 nm), without the need for a Lewis acid promoter. A solid-phase extraction method was established to give [Ga F F (BnMe -tacn)] in 99 % radiochemical purity in an EtOH/H O mixture.
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| http://dx.doi.org/10.1002/anie.201802446 | DOI Listing |
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