Subjective memory change (SMC) in adulthood involves the perception that one's memory has declined from earlier levels of function. SMC has been conjectured to be more accurate than concurrent subjective memory because people use themselves as a standard of comparison. We used data from two longitudinal studies to contrast the accurate-monitoring-of-change hypothesis-actual memory change predicts SMC-against a constructed-judgment hypothesis that rated SMC is a function of rescaling concurrent memory beliefs without accessing actual memory change. It states that actual memory change has no predictive validity for SMC independent of concurrent memory beliefs. Data from both the Berlin Aging Study and the Health and Retirement Study (HRS) showed that older adults' current memory complaints strongly predicted current SMC, and that there was little relationship of longitudinally measured memory change to SMC, controlling on memory complaints. In the HRS there were reliable latent-growth-curve slope correlations of over .20 for change in episodic memory with both slopes of change in SMC and in memory complaints, yet little relationship of SMC slopes to episodic memory slopes, controlling on memory-complaint slopes. The results falsify the accurate-monitoring-of-change hypothesis regarding the origins of SMC in older adults. (PsycINFO Database Record
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http://dx.doi.org/10.1037/pag0000232 | DOI Listing |
Alzheimers Dement
December 2024
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Introduction: Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.
Methods: Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas (LaftamBio Pampa), Universidade Federal do Pampa, Itaqui, RS, Brazil. Electronic address:
Amphetamine (AMPH) abuse represents a major global public health issue, highlighting the urgent need for effective therapeutic interventions to manage addiction caused by this psychostimulant. This study aimed to assess the potential of m-trifluoromethyl-diphenyldiselenide [(m-CF-PhSe)] in preventing the addictive effects induced by AMPH through targeting dopamine metabolism proteins. (m-CF-PhSe) is of interest due to its demonstrated efficacy in mitigating opioid abuse, establishing it as a promising candidate for addiction treatment research.
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State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China. Electronic address:
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National Centre for Asbestos Related Diseases, Institute for Respiratory Health, Nedlands, WA 6009, Australia; School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia; The Kids Research Institute, University of Western Australia, Nedlands WA 6009, Australia. Electronic address:
Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N = 54).
View Article and Find Full Text PDFEur J Med Chem
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Kantara Branch, Ismailia, 41636, Egypt.
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