Endarterectomy was performed in vivo using a high speed rotating abrasive-tipped catheter device in 11 normal canine coronary arteries. The device is designed to remove atheromatous material from diseased arteries by the abrasive action of its rotating tip. It was operated percutaneously from a femoral approach using conventional angioplasty guiding equipment. The rotating device was advanced over a guide wire from just beyond the tip of the guide catheter into the distal vessel. Six arteries were harvested immediately after endarterectomy and five were left in place for 7 +/- 2.8 days; in the latter group, the animals were maintained on a regimen of aspirin, 325 mg/day. Angiography before and after treatment demonstrated vessel patency in all cases. Caliper-measured luminal diameters were not significantly changed after endarterectomy. Histologic examination of pressure-fixed vessels showed extensive intimal loss and 20 to 30% loss of the internal elastic lamina. Medial damage was superficial and never exceeded 40% of the total medial thickness. There were no vessel perforations. Results of histologic study of the myocardium supplied by the treated vessels were normal without evidence of distal embolization or infarction. It is concluded that a high speed rotating abrasive device can be safely operated percutaneously in normal coronary arteries and results in minimal vessel damage and continued patency at 7 +/- 2.8 days.
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