AI Article Synopsis
- - A serologic study investigated the rate of asymptomatic MERS coronavirus infection among healthcare and non-healthcare workers, focusing on individuals exposed to MERS patients during the 2015 outbreak.
- - Out of 1,610 contacts tested, only 7 were found ELISA-positive, leading to an overall asymptomatic infection rate of 0.060%, with just one case confirmed through additional testing.
- - The confirmed asymptomatic case involved a hospitalized individual with pre-existing health conditions and highlights the importance of expanding serologic studies to include asymptomatic hospital contacts.
Article Abstract
Objectives: The rates of asymptomatic infection with Middle East Respiratory Syndrome (MERS) coronavirus vary. A serologic study was conducted to determine the asymptomatic MERS infection rate in healthcare workers and non-healthcare workers by exposure status.
Methods: Study participants were selected from contacts of MERS patients based on a priority system in 4 regions strongly affected by the 2015 MERS outbreak. A sero-epidemiological survey was performed in 1,610 contacts (average duration from exposure to test, 4.8 months), and the collected sera were tested using an enzyme-linked immunespecific assay (ELISA), immunofluorescence assay (IFA), and plaque reduction neutralization antibody test (PRNT). Among the 1,610 contacts, there were 7 ELISA-positive cases, of which 1 exhibited positive IFA and PRNT results.
Results: The asymptomatic infection rate was 0.060% (95% confidence interval, 0.002 to 0.346). The asymptomatic MERS case was a patient who had been hospitalized with patient zero on the same floor of the hospital at the same time. The case was quarantined at home for 2 weeks after discharge, and had underlying diseases, including hypertension, angina, and degenerative arthritis.
Conclusions: The asymptomatic infection was acquired via healthcare-associated transmission. Thus, it is necessary to extend serologic studies to include inpatient contacts who have no symptoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968208 | PMC |
| http://dx.doi.org/10.4178/epih.e2018014 | DOI Listing |
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