AI Article Synopsis
- Chemerin is a protein in the body that is important for heart diseases and problems with blood vessels.
- In a study of 178 patients with severe carotid artery blockages, they found that chemerin levels were higher than in 163 healthy people.
- Higher chemerin is linked to higher inflammation and can increase the risk of heart disease in these patients.
Article Abstract
Background: Chemerin is an adipokine which plays a crucial role in atherosclerosis. Here, we examined whether circulating chemerin is enhanced in patients with advanced carotid stenosis.
Methods: Chemerin was quantified in 178 patients prior to carotid end arterectomy (CEA) and in age- and gender-matched controls (n = 163). Chemerin levels were related to anthropometric, clinical and metabolic characteristics of the patients.
Results: Chemerin levels were higher in patients compared to controls (p < 0.001). Chemerin correlated to parameters associated with inflammation such as C-reactive protein (CRP, p < 0.001), leukocyte blood count (p < 0.001) and circulating TNF-α (p = 0.004) in the patients. Chemerin levels did not differ between asymptomatic (n = 93) and symptomatic patients who experienced an ischemic event within 6 months prior to CEA (n = 85). However, in the case of high-grade carotid stenosis (≥ 90%), chemerin levels were higher in symptomatic (n = 44) compared to asymptomatic patients (n = 41, p = 0.014). Chemerin was increased in patients with (n = 50) compared to patients without (n = 128) coronary artery disease (CAD, p = 0.002). A high level of chemerin increases the risk for CAD in patients (p = 0.0013).
Conclusions: Circulating chemerin is increased and correlates to inflammatory parameters in patients with advanced carotid stenosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899364 | PMC |
| http://dx.doi.org/10.1186/s12872-018-0803-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Common Genetic Factors May Play a Role in the Relationships Between Body Composition, Adipokines, and Low-Back-Pain-Related Disability.
Biomolecules
November 2024
Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
Article Synopsis
- * It used family-based statistical analysis methods to find that there is a significant genetic component influencing both LBP_DS and the measured body composition aspects and adipokines.
- * The results suggest that different genetic factors impact LBP_DS, showing a complex relationship where adipokine variations and body composition measurements may independently affect back pain disability without overlapping genetic influences.
Circulating chemerin and interleukin-6 in children with obesity: possible metabolic risk predictors.
Transl Pediatr
October 2024
Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Background: As the incidence of childhood obesity has risen significantly and it can result in many complications in adulthood, this study aimed to provide a new view for early prevention of childhood obesity by detecting the levels of interleukin-6 (IL-6) and chemerin in children and studying the clinical significance.
Methods: We used a case-control design. Serum chemerin and IL-6 levels were measured among 101 participants, including 50 children with obesity and 51 healthy children.
Vascular chemerin from PVAT contributes to norepinephrine and serotonin-induced vasoconstriction and vascular stiffness in a sex-dependent manner.
Am J Physiol Heart Circ Physiol
December 2024
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States.
The adipokine chemerin supports normal blood pressure and contributes to adiposity-associated hypertension, evidenced by falls in mean arterial pressure in Dahl SS rats given an antisense oligonucleotide against chemerin. In humans, circulating chemerin is positively associated with hypertension and aortic stiffness. Mechanisms of chemerin's influence on vascular health and disease remain unknown.
View Article and Find Full Text PDFCirculating Chemerin Levels in Obese and Non-obese Individuals and Its Association With Obesity in Metabolic Dysfunction-Associated Fatty Liver Disease.
Cureus
August 2024
Department of Internal Medicine, SRM Medical College Hospital and Research Centre, Chengalpattu, IND.
Article Synopsis
- The study investigates the link between obesity, chemerin levels, and metabolic disorders like MAFLD, highlighting rising obesity rates tied to lifestyle and dietary changes.
- Results show a significant prevalence of MAFLD (44%) in obese individuals compared to non-obese (33%) and indicate differences in metabolic markers like fasting plasma glucose and triglycerides, but no direct association between chemerin levels and MAFLD or BMI was found.
- The research utilized various methods including diagnostic criteria for MAFLD, a physical activity questionnaire, and statistical analyses to compare results between obese and non-obese participants at a medical center in Tamil Nadu.
Chemerin Levels in COVID-19 Are More Affected by Underlying Diseases than by the Virus Infection Itself.
Biomedicines
September 2024
Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, 93053 Regensburg, Germany.
Background/objectives: Chemerin is an adipokine involved in inflammatory and metabolic diseases, and its circulating levels have been associated with inflammatory parameters in various patient cohorts. Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, which causes COVID-19, triggers inflammatory pathways. However, the association between serum chemerin levels and COVID-19 disease severity and outcomes has not been definitively established.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!