Introduction: The anterior and middle superior alveolar nerve block was claimed to be unpredictably efficient for clinical application.

Objective: The aim of this report was to establish the efficacy of the anterior and middle superior alveolar nerve block, applied with a computer-controlled injection system or a conventional syringe, for upper premolars extraction.

Methods: Sixty healthy adults were divided into two groups regarding the device used as follows: the first group was injected by a computer-controlled injection system, and the second group by a conventional syringe. Pain ratings were obtained via a visual analog scale (VAS) and a verbal rating scale (VRS).

Results: Anterior and middle superior alveolar injection enabled a painless extraction in all patients, regardless of the local anesthetic or injection system used. It was slightly less painful when administered by a computer-controlled injection system, but insignificantly when evaluated by VRS.

Conclusion: The anterior and middle superior alveolar nerve block may be recommended if maxillary permanent premolars have to be extracted.

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