Even though pneumococcal vaccination recommendations have been in existence since 1983, vaccination rates are low in the United States. This study analyzed 5-year trends in pneumococcal polysaccharide vaccination uptake across racial/ethnic groups of individuals aged ≥65 years and high-risk individuals aged 19-64 years. Further, it examined factors that may explain the association between race/ethnicity and vaccination uptake. The 2011-2015 annual Behavioral Risk Factor Surveillance System (BRFSS) data were used to determine trends. The Behavioral Model of Health Care Utilization was used to identify covariates in the model. Multivariate logistic regressions were used to identify the association between race/ethnicity and vaccination uptake from 2015 BRFSS. Overall, from 2011 to 2015, vaccination uptake increased moderately from 69% to 71% among those aged ≥65 years, and from 21% to 24% for high-risk individuals aged 19-64 years. Among those aged ≥65 years (n = 99,403), African Americans (adjusted odds ratio [AOR]: 1.36, 95%CI: 1.21-1.52) and Hispanics (AOR: 2.13, 95%CI: 1.85-2.46) were more likely to be vaccinated than Whites. Among the younger population (n = 177,976), African Americans (AOR: 0.85, 95%CI: 0.79-0.92) and Asians (AOR: 0.73, 95%CI: 0.63-0.84) were less likely to be vaccinated than Whites. Over the 5 years there were no significant increases in vaccination uptake. The rates are far below the Healthy People 2020 goals. Reverse disparities were observed in the older group. In younger group, minorities were less likely to get vaccinated. As gaps still exist, this study implies tailored interventions based on race/ethnicity to promote vaccination uptake among both groups.
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http://dx.doi.org/10.1089/pop.2017.0176 | DOI Listing |
Gerontologist
January 2025
Population Health Initiative, University of Washington, Seattle, WA, USA.
Background And Objectives: The study aimed to identify key drivers of vaccine hesitancy among healthcare workers (HCWs) employed at Long-term care facilities (LTCF) within selected states. It also sought to determine which interventions, policies, and programs effectively reduced HCW vaccine hesitancy for COVID-19 and influenza.
Research Design And Methods: The study employed a mixed methods approach, combining secondary analysis of the Behavioral Risk Factor Surveillance System (BRFSS) data, survey research, and focus groups.
Angew Chem Int Ed Engl
January 2025
University of Science and Technology of China School of Biomedical Engineering, Department of Polymer Science and Engineering, 96 Jinzhai Road, 230026, Hefei, CHINA.
Lipid nanoparticles (LNPs) based messenger RNA (mRNA) therapeutics hold immense promise for treating a wide array of diseases, while their nonhepatic organs targeting and insufficient endosomal escape efficiency remain challenges. For LNPs, polyethylene glycol (PEG) lipids have a crucial role in stabilizing them in aqueous medium, but they severely hinder cellular uptake and reduce transfection efficiency. In this study, we designed ultrasound (US)-assisted fluorinated PEGylated LNPs (F-LNPs) to enhance spleen-targeted mRNA delivery and transfection.
View Article and Find Full Text PDFNiger Med J
January 2025
Department of Community Medicine, University of Jos, Jos, Plateau State, Nigeria.
Background: COVID-19 vaccination is crucial to containing the pandemic. COVID-19 vaccine knowledge, attitudes, and uptake among medical students are vital, as they are future healthcare professionals expected to promote vaccination. This study assessed the knowledge of the COVID-19 vaccine, its uptake, and associated factors among medical students.
View Article and Find Full Text PDFBackground Tuberculosis (TB) remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the infection. Bacterial persistence during exposure to bactericidal antibiotics is at least partially mediated by the bacterial stringent response enzyme, Rel .
View Article and Find Full Text PDFJ Dent Sci
January 2025
Department of Stomatology, Taichung Veterans General Hospital, Taichung, Taiwan.
Background/purpose: COVID-19 vaccines are supplied at no-cost to residents as a measure to prevent comorbidities, fatalities, and the increased risk of community transmission, thus protecting public health systems. However, vaccine acceptance among cancer patients remained uncertain. This study aimed to elucidate the vaccination rates among oral cancer patients at a medical center in Taiwan.
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