A set of arylpiperazine derivatives with imide fragments, 1-(1H-pyrrol-1-ylmethyl)-10-oxa-4-azatricyclo[5.2.1.0(2,6)-]dec-8-ene-3,5-dione connected by propyl and butyl linkers, were synthesized and tested for the potential anxiolytic and antidepressant activities. Compounds 3a and 3b demonstrated antidepressant activity in the forced swimming tests in mice and were devoid of neurotoxic effects. (chimney test in mice).
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
synthesis structure
4
structure pharmacological
4
pharmacological evaluation
4
evaluation 1-1h-pyrrol-1-ylmethyl-4-azatricyclo[521026]
4
1-1h-pyrrol-1-ylmethyl-4-azatricyclo[521026] dec-8-ene-35-dione
4
dec-8-ene-35-dione set
4
set arylpiperazine
4
arylpiperazine derivatives
4
derivatives imide
4
imide fragments
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!