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Galectin-4 Antimicrobial Activity Primarily Occurs Through its C-Terminal Domain.
Mol Cell Proteomics
May 2024
Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
Although immune tolerance evolved to reduce reactivity with self, it creates a gap in the adaptive immune response against microbes that decorate themselves in self-like antigens. This is particularly apparent with carbohydrate-based blood group antigens, wherein microbes can envelope themselves in blood group structures similar to human cells. In this study, we demonstrate that the innate immune lectin, galectin-4 (Gal-4), exhibits strain-specific binding and killing behavior towards microbes that display blood group-like antigens.
View Article and Find Full Text PDFIntestinal Norovirus Binding Patterns in Nonsecretor Individuals.
J Virol
October 2022
National Reference Centre for Gastroenteritis Viruses, Laboratory of Virology, University Hospital of Dijon, Dijon, France.
Human norovirus (HuNoV) infection is associated with an active FUT2 gene, which characterizes the secretor phenotype. However, nonsecretor individuals are also affected by HuNoV infection although in a lesser proportion. Here, we studied GII.
View Article and Find Full Text PDFKindergarteners Use Cross-Situational Statistics to Infer the Meaning of Grammatical Elements.
J Psycholinguist Res
December 2022
Amsterdam Center for Language and Communication, University of Amsterdam, Spuistraat 134, 1012 VB, Amsterdam, The Netherlands.
Many studies demonstrate that detecting statistical regularities in linguistic input plays a key role in language acquisition. Yet, it is unclear to what extent statistical learning is involved in more naturalistic settings, when young children have to acquire meaningful grammatical elements. In the present study, we address these points, by investigating whether statistical learning is involved in acquiring a morpho-syntactic structure from input that resembles natural languages more closely.
View Article and Find Full Text PDFGalectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group-like antigens.
J Biol Chem
April 2022
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
While adaptive immunity recognizes a nearly infinite range of antigenic determinants, immune tolerance renders adaptive immunity vulnerable to microbes decorated in self-like antigens. Recent studies suggest that sugar-binding proteins galectin-4 and galectin-8 bind microbes expressing blood group antigens. However, the binding profile and potential antimicrobial activity of other galectins, particularly galectin-9 (Gal-9), has remained incompletely defined.
View Article and Find Full Text PDFCauses of burnout syndrome and coping strategies among high dependency unit nurses of an institution in the greater Accra region of Ghana.
Nurs Open
November 2021
School of Nursing and Midwifery, University of Cape Coast, Cape Coast, Ghana.
Aim: The aim of this study was to determine the causes of burnout syndrome and identify strategies to cope with them among nurses at high dependency unit if a regional Hospital in Ghana.
Design: A descriptive convenient and purposive cross-sectional study design was used for this study.
Methods: The study involved 40 nurses in the high dependency unit of the Hospital.
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