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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881219 | PMC |
http://dx.doi.org/10.21037/tau.2017.09.20 | DOI Listing |
Transl Androl Urol
September 2024
Department of Urology, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Clin Rheumatol
October 2024
Center for Arthritis and Rheumatic Diseases, Kawasaki Municipal Kawasaki Hospital, Kanagawa, Japan.
Bladder Cancer
June 2024
Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: The intravesical gene therapy nadofaragene firadenovec (rAd-IFNα/Syn3) was FDA approved in 2022 for non-muscle invasive bladder cancer (NMIBC) unresponsive to frontline treatment with BCG, and the first gene therapy developed for bladder cancer. This non-replicating recombinant adenovirus vector delivers a copy of the human interferon alpha-2b gene into urothelial and tumor cells, causing them to express this pleotropic cytokine with potent antitumor effects.
Objective: To provide a historical overview describing how several decades of preclinical and clinical studies investigating the role of interferon in the treatment of bladder cancer ultimately led to the development of gene therapy with nadofaragene for NMIBC.
Bladder Cancer
December 2023
Department of Urology, Clinica Alemana Universidad del Desarrollo, Santiago, Chile.
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