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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261622 | PMC |
| http://dx.doi.org/10.1017/S1368980018000022 | DOI Listing |
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Design of INSPIRE: Evaluation of the effectiveness of practice facilitation on implementation of screening, brief interventions, referral to treatment and medication for unhealthy alcohol use identification and treatment in primary care.
Contemp Clin Trials Commun
February 2025
Department of Medicine, Division of General Internal Medicine and Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, USA.
Background: Unhealthy alcohol use is a leading cause of preventable mortality and a risk factor for an array of social and health problems. The Intervention in Small primary care Practices to Implement Reduction in unhealthy alcohol use (INSPIRE) study is part of a nationwide campaign to improve the identification and treatment of patients engaging in unhealthy alcohol use.
Methods: We conducted a single arm, pragmatic study consisting of seventeen primary care practices in the Chicago metropolitan area, Wisconsin, and California across two waves with a 6-month latent period, a 12-month intervention period, followed by a 6-month sustainability period.
A multilevel framework for recruitment and retention in implementation trials: An illustrative example.
Clin Trials
January 2025
Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Background: Implementation and hybrid effectiveness-implementation trials aspire to speed the translation of science into practice by generating crucial evidence for improving the uptake of effective health interventions. By design, they pose unique recruitment and retention challenges due to their aims, units of analysis, and sampling plans, which typically require many clinical sites (i.e.
View Article and Find Full Text PDFMachine Learning and Computed Tomography Radiomics to Predict Disease Progression to Upfront Pembrolizumab Monotherapy in Advanced Non-Small-Cell Lung Cancer: A Pilot Study.
Cancers (Basel)
December 2024
BC Cancer, Vancouver Center, 600 West 10th Avenue, Vancouver, BC V5Z 4E6, Canada.
Background/objectives: Pembrolizumab monotherapy is approved in Canada for first-line treatment of advanced NSCLC with PD-L1 ≥ 50% and no EGFR/ALK aberrations. However, approximately 55% of these patients do not respond to pembrolizumab, underscoring the need for the early intervention of non-responders to optimize treatment strategies. Distinguishing the 55% sub-cohort prior to treatment is a real-world dilemma.
View Article and Find Full Text PDFChallenges and Lessons from an Acute Telehealth Homeopathy Service During the Pandemic: A Case Series Exploring How Changing Demographics, Efficiency and Outcomes, Point to New Options for Epidemic Readiness.
Healthcare (Basel)
December 2024
HOHM Foundation, Philadelphia, PA 19138, USA.
In 2020, HOHM Foundation launched Homeopathy Help Now (HHN), a network of professional homeopathy telehealth practitioners, administrative volunteers, and independent researchers to work collaboratively in order to respond to the urgent need of care for the ever-growing number of COVID-19 cases in the United States. in this pragmatic case series study, cases of positively testing or probable COVID-19 (n = 3495) are analyzed using conventional quantitative analysis. The sample includes clinical data collected from clients who attended the clinic between 23 March 2020 and 31 December 2023.
View Article and Find Full Text PDFImplementing Namaste Care in nursing care homes for people with advanced dementia: a systematically constructed review with framework synthesis.
BMC Geriatr
January 2025
International Observatory on End of Life Care, Lancaster University, Lancaster, UK.
Background: Namaste Care is an intervention designed to improve the quality of life for people with advanced dementia by providing individualised stimulation and personalised activities in a group setting. Current evidence indicates there may be benefits from this intervention, but there is a need to explore the practical realities of its implementation, including potential barriers, enablers, and how it is delivered within the context of nursing care homes.
Objective: To systematically assess the factors involved in implementing Namaste Care for people with advanced dementia in nursing care homes.
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