Samter's Triad: State of the Art.

Clin Exp Otorhinolaryngol

Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Published: June 2018

AI Article Synopsis

  • Samter's triad (ST) is defined by three main conditions: bronchial asthma, nasal polyps, and aspirin intolerance, with increasing understanding of its causes and characteristics in recent years.
  • The paper aims to summarize recent research on the underlying mechanisms, genetic factors, diagnosis, and treatment options for ST, enhancing knowledge for better management of the disease.
  • There's an emphasis on the growing necessity for aspirin desensitization in treatment and the ongoing need for research into ST's pathophysiology, treatment strategies, and preventive measures.

Article Abstract

Samter's triad (ST) is a well-known disease characterized by the triad of bronchial asthma, nasal polyps, and aspirin intolerance. Over the past few years, a rapid development in the knowledge of the pathogenesis and clinical characteristics of ST has happened. The aim of this paper is to review the recent investigations on the pathophysiological mechanisms and genetic background, diagnosis, and different therapeutic options of ST to advance our understanding of the mechanism and the therapeutic control of ST. As concern for ST increase, more application of aspirin desensitization will be required to manage this disease successfully. There is also a need for continued research efforts in pathophysiology, treatment, and possible prevention.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951071PMC
http://dx.doi.org/10.21053/ceo.2017.01606DOI Listing

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