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| http://dx.doi.org/10.2147/AMEP.S161389 | DOI Listing |
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Potential mutagenicity of aflatoxin B1 in Egyptian spices.
BMC Genomics
January 2025
Botany Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
The current study aimed to detect the mutagenic impacts of aflatoxin B1 (AFB1), which is produced by Aspergillus group fungi, via a high-plant genotoxicity test. Different durations of treatment (3 h, 6 h, and 12 h) were used to treat the Vicia faba root tips with varying concentrations of Aflatoxin B1 (AFB1) following the approved protocol for plant assays published by the International Program on Chemical Safety (IPCS) and the World Health Organization (WHO). The data obtained indicated that AFB1 not only has the ability to induce various alterations in the process of mitosis, ranging from increasing to decreasing mitotic and phase indices but also leads to many mitotic aberrations.
View Article and Find Full Text PDFMechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells.
Cell Biochem Biophys
January 2025
Faculty of Medicine, Department of Histology and Embryology, Eskişehir Osmangazi University, Eskişehir, Türkiye.
Article Synopsis
- Silymarin, a flavonoid from milk thistle, shows promising effects like antioxidant and anti-inflammatory properties, particularly in cancer research.
- In a study on SPC212 human mesothelioma cells, silymarin was found to have a dose-dependent cytotoxic effect, with a half-maximal inhibitory concentration (IC) of about 187.5 µM.
- The compound induced signs of apoptosis, such as cell shrinkage and nuclear changes, suggesting its potential as an anti-cancer agent that needs further investigation.
TFEB Phase Separation Mediates the Amelioration Effect of Intermittent Fasting on Inflammatory Colitis.
Inflammation
December 2024
Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Intermittent fasting (IF) has been shown to ameliorate inflammation including DSS-induced colitis. It is well known that autophagy can limit inflammation and TFEB is a master transcriptional factor that regulates the processes of autophagy. However, whether TFEB is involved in the regulation of IF-mediated amelioration of inflammation and its mechanism remained unclear.
View Article and Find Full Text PDFEP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.
Andrology
November 2024
Department of Histology and Embryology, School of Basic Medical Sciences, State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
Background: Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout. EP300-interacting inhibitor of differentiation 3 (Eid3) is a testis-enriched gene, but its role in male reproduction remains unclear.
View Article and Find Full Text PDFHURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2.
Nat Commun
November 2024
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Article Synopsis
- Most vertebrate spindles utilize branching microtubule nucleation, where new microtubules form alongside existing ones.
- The study highlights the role of hepatoma up-regulated protein (HURP) in this process, showing it is essential for RanGTP-induced microtubule branching in Xenopus egg extract.
- HURP stabilizes the microtubule structure and shifts its function toward facilitating branching by localizing to TPX2 condensates, which are crucial for spindle assembly, supported by high-resolution cryo-EM imaging of HURP on microtubules.
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