Background: Depression in pregnancy is commonly treated using selective serotonin reuptake inhibitors (SSRIs). A possible withdrawal syndrome following in utero exposure has been reported, but there is currently no UK guidance on the management of these neonates.
Methods: All 160 neonatal units in England were asked for information regarding their management of SSRI-exposed babies.
Results: Responses were obtained from 112/160 (70%) units. Only four units had a specific protocol for managing SSRI-exposed neonates. Twenty-one units (19%) conduct routine observations on exposed neonates, while 37 units (33%) would consider treating babies with signs of withdrawal or toxicity.
Conclusions: Very few neonatal units in England have specific guidelines for the management of babies exposed to SSRIs in utero, with practice varying greatly between units. Further research is needed on the outcomes of SSRI-exposed babies to support development of standardised evidence-based guidelines to ensure all mothers and babies receive similar high-quality care.
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http://dx.doi.org/10.1136/bmjpo-2017-000060 | DOI Listing |
Pharmacology
December 2024
Hematology Department, University Hospital Dubrava, Zagreb, Croatia.
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative agent of coronavirus disease 2019 (COVID-19), a very contagious systemic disease dominantly affecting the respiratory tract. Recent findings oppose earlier suggestions that selective serotonin reuptake inhibitors (SSRIs) might be protective during acute SARS-CoV-2 infection, prompting the current study.
Methods: The institutional registry of a tertiary referral center was retrospectively evaluated for SSRI use and associated clinical outcomes among hospitalized COVID-19 patients with mostly severe and critical disease.
Biol Psychiatry Cogn Neurosci Neuroimaging
January 2019
Division of Developmental Pediatrics, University of British Columbia, Vancouver, Canada; Research Institute, BC Children's Hospital, Vancouver, Canada. Electronic address:
Background: Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression during pregnancy. SSRIs cross the placenta, inhibit serotonin reuptake, and thereby are thought to alter central fetal serotonin signaling. Both prenatal maternal mood disturbances and in utero SSRI exposure have been associated with altered fetal and infant behavior.
View Article and Find Full Text PDFBMJ Paediatr Open
August 2017
Department of Paediatrics, Great Western Hospital, Swindon, UK.
Background: Depression in pregnancy is commonly treated using selective serotonin reuptake inhibitors (SSRIs). A possible withdrawal syndrome following in utero exposure has been reported, but there is currently no UK guidance on the management of these neonates.
Methods: All 160 neonatal units in England were asked for information regarding their management of SSRI-exposed babies.
Acta Psychiatr Scand
June 2018
Mental Health Centre, Copenhagen University Hospital, Glostrup, Denmark.
Objective: Data on special education in offspring exposed to selective serotonin reuptake inhibitors (SSRIs) in utero are lacking. We examined associations of in utero SSRI exposure with special education needs and delayed elementary school start.
Methods: A population-based case-cohort study using Danish nationwide birth and prescription registry data from 2005 to 2008.
J Clin Psychiatry
November 2017
Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan.
Objective: Exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to increase the risk of stroke. In this study, we investigated age and time effects on the risk of first onset stroke in SSRI-exposed (SSRIEXP) adult subjects.
Methods: We analyzed an 8-year cohort from the National Health Insurance Research Database, Taiwan.
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