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Current state of proton therapy for tumors of the central nervous system in Spain: physical bases, indications, controversies and perspectives.
Clin Transl Oncol
August 2024
Servicio de Neurocirugía, Hospital Universitario de Burgos, Avda Islas Baleares 3, 09006, Burgos, Spain.
The unique biophysical properties of proton therapy (PT), regarding the precise dose distribution, a remarkable better sparing of surrounding normal tissues, and the decreasing costs have promoted the spread of this technique worldwide. In Spain, eleven new PT centers, added to the currently two in function, are expected to be available in the near future. Indications for PT are currently evolving.
View Article and Find Full Text PDFAmbulatory blood pressure monitoring. Current status and future perspectives.
Med Clin (Barc)
July 2024
Unidad de Hipertensión, Servicio de Medicina Interna, Hospital Mútua Terrassa, Universidad de Barcelona, Barcelona, España. Electronic address:
Ambulatory Blood Pressure Monitoring (ABPM) is considered the best method for obtaining a reliable estimation of the true blood pressure. Average values obtained during the whole 24-hour period, or during daytime and nighttime periods are better correlated with the risk of mortality and cardiovascular disease compared to clinic or office blood pressure. Indeed, nighttime blood pressure, a measure only obtained through ABPM, is the most powerful risk predictor.
View Article and Find Full Text PDF[Autoimmunity in chronic urticaria. A historical and current perspective].
Rev Alerg Mex
January 2022
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Servicio de Inmunología Clínica y Alergia, Ciudad de México, México,
Chronic spontaneous urticaria is a condition that persists for more than six weeks, it occurs in the absence of an identifiable triggering factor and from the pathogenic activation of mast cells and basophils. The possibility of autoimmune etiology in up to 40 % of patients is presented, followed by subclinical infections and psychological factors. Two main mechanisms of the pathogenesis of chronic urticaria have been proposed: the former is the dysregulation of intracellular signaling pathways within mast cells and basophils, which leads to defects in the traffic or function of these cells.
View Article and Find Full Text PDF[Cervical cancer screening in Spain: Historical perspective, current status, and recommendations for the future].
Rev Esp Patol
March 2022
Servicio de Anatomía Patológica, Hospital Clinic de Barcelona, Universidad de Barcelona, Research Professor, ISGlobal, Barcelona, España. Electronic address:
Chimeric antigen receptor T-cell (CAR-T) therapy in patients with aggressive B-cell lymphomas. Current outlook after a decade of treatment.
Med Clin (Barc)
April 2022
Department of Hematology, University Hospital Vall d'Hebron, Barcelona, España; Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, España; Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, España. Electronic address:
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the management of patients with diffuse large B-cell lymphoma (DLBCL) who are refractory or relapse after immunochemotherapy. This strategy consists in genetically modifying the patient's own T lymphocytes to favor the recognition of selected tumor antigens. Currently, we have two anti-CD19 CAR-T drugs approved in Spain for patients with DLBCL after two or more prior treatment lines and there are multiple ongoing clinical trials exploring earlier lines of treatment.
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