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The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research.
CNS Drugs
January 2025
School of Population and Global Health, University of Western Australia, Nedlands, WA, 6009, Australia.
Article Synopsis
- - The study reviews the safety concerns of various alcohol pharmacotherapies during pregnancy, as current options for pregnant individuals with alcohol use disorders (AUD) are limited due to unknown teratogenic risks.
- - A total of 105 studies were analyzed, focusing on medications like naltrexone, acamprosate, disulfiram, and topiramate, with findings suggesting that naltrexone might be safer than other options for opioid use disorders, despite being less studied for AUD specifically.
- - The review highlights significant safety concerns, noting disulfiram and topiramate's links to congenital anomalies, while acamprosate showed potential neuroprotective benefits without clear adverse effects, creating a complex picture of risks and benefits
In response to "Gabapentinoid prescribing patterns and predictors utilizing neural networks: Comment".
Am J Emerg Med
December 2024
Georgetown University, School of Medicine, United States of America; Department of Emergency Medicine, MedStar Washington Hospital Center, United States of America.
Patient-Directed Education to Promote Deprescribing: A Nonrandomized Clinical Trial.
JAMA Intern Med
November 2024
New England Geriatric Research Education and Clinical Center, VA Boston Health Care System, Jamaica Plain, Massachusetts.
Article Synopsis
- The study investigates how patient-directed educational materials can help clinicians reduce unnecessary prescriptions for specific medication groups, notably proton pump inhibitors and high-risk diabetes treatments.
- Conducted across three VA medical centers, the trial involved 5071 patients and compared an intervention cohort receiving educational brochures to a control group from the previous year.
- Results showed a higher deprescribing rate among the intervention group (29.5%) compared to the control group (25.8%), indicating that the educational intervention positively affected medication management practices.
Diagnostic and therapeutic insights in individuals with persistent post-dural puncture headache: A cross-sectional study.
Headache
September 2024
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Background: Post-dural puncture headache (PDPH) is a frequent complication following lumbar puncture, epidural analgesia, or neuraxial anesthesia. The International Classification of Headache Disorders, third edition categorizes PDPH as a self-limiting condition; however, emerging evidence, including our findings, suggests that PDPH can have a prolonged course, challenging this traditional view.
Objectives: To elucidate the diagnostic characteristics and treatment outcomes of persistent PDPH (pPDPH), offering insights into its demographic profiles and diagnostic features.
[Not Available].
MMW Fortschr Med
June 2024
Klinik für Pneumologie, Frankfurter Rotkreuz-Kliniken, Königswarterstr. 16, 60316, Frankfurt am Main, Deutschland.
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