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Heterotopic Triplet Pregnancy After Assisted Reproductive Techniques: A Systematic Review.
Cureus
December 2024
Department of Obstetrics and Gynecology, School of Health Sciences, University of Patras, Patras, GRC.
Heterotopic pregnancy is defined as the simultaneous presence of an intrauterine and an extrauterine pregnancy and is considered a rare condition. As a part of this entity, heterotopic triplet pregnancy, defined as the presence of three embryos, with at least one being ectopic, is exceedingly rare. In recent years, the broad use of assisted reproductive techniques to help infertile couples has contributed to the constant rise of non-spontaneous heterotopic triplets.
View Article and Find Full Text PDFExercise interventions to improve bone mineral density in athletes participating in low-impact sports: a scoping review.
BMC Musculoskelet Disord
January 2025
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Background: Athletes participating in low-impact sports such as cycling and swimming are at increased risk for low bone mineral density, which may lead to long-term health issues. Exercise is known to increase bone mineral density, but there is little knowledge of the effects of this in athletes participating in low-impact sports. This review aims to identify potential exercise interventions that could improve bone health in these athletes.
View Article and Find Full Text PDFTwenty years of advances in prediction of nucleic acid-binding residues in protein sequences.
Brief Bioinform
November 2024
Department of Computer Science, Virginia Commonwealth University, 401 West Main Street, Richmond, VA 23284, United States.
Computational prediction of nucleic acid-binding residues in protein sequences is an active field of research, with over 80 methods that were released in the past 2 decades. We identify and discuss 87 sequence-based predictors that include dozens of recently published methods that are surveyed for the first time. We overview historical progress and examine multiple practical issues that include availability and impact of predictors, key features of their predictive models, and important aspects related to their training and assessment.
View Article and Find Full Text PDFBinding of ligands to the aryl hydrocarbon receptor: An overview of methods.
Toxicol Lett
January 2025
Department of Cell Biology and Genetics, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic. Electronic address:
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which plays numerous and pivotal roles in human physiology and pathophysiology. Therefore, pharmacotherapeutic targeting of the AhR is a highly pertinent issue. The identification of new AhR ligands and the characterization of the interactions between the AhR ligands and AhR protein requires appropriate methodology.
View Article and Find Full Text PDFImproving systemic delivery of oncolytic virus by cellular carriers.
Cancer Biol Med
January 2025
Houston Methodist Cancer Center/Weill Cornell Medicine, Houston, TX 77030, USA.
Oncolytic virotherapy (OVT) is a promising option for cancer treatment. OVT involves selective oncolytic virus (OV) replication within cancer cells, which triggers anti-tumor responses and immunostimulation. Despite promising potential, OVT faces critical challenges, including insufficient tumor-specific targeting, which results in limited tumor penetration and variability in therapeutic efficacy.
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