The inheritance of heterochromatic regions of chromosomes 1, 9, 16 and Y was studied in twelve families by means of measuring their C-segments. Maternal and paternal origin of chromosomes 1, 9 and 16 in the child was determined by two methods. The advantages and disadvantages of these methods and possibilities of their application are under discussion.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
OCT analysis and MPOD assessment in patients affected by retinitis pigmentosa.
Sci Rep
November 2024
Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy.
This study aimed to analyze Optical Coherence Tomography (OCT) parameters and Macular Pigment Optical Density (MPOD) changes in patients affected by Retinitis pigmentosa (RP). Eighteen eyes of 18 patients suffering from early-stage RP were enrolled in our observational study. 18 eyes of 18 patients age and gender matched were enrolled as controls.
View Article and Find Full Text PDFSupernumerary Chromosomes Enhance Karyotypic Diversification of Narrow-Headed Voles of the Subgenus Stenocranius (Rodentia, Mammalia).
J Exp Zool B Mol Dev Evol
December 2024
Laboratory of Evolutionary Genomics and Paleogenomics, Zoological Institute, Russian Academy of Sciences, Saint-Petersburg, Russia.
The subgenus Stenocranius contains two cryptic species: Lasiopodomys gregalis (subdivided into three allopatrically distributed and genetically well-isolated lineages A, B, and C) and Lasiopodomys raddei. To identify karyotype characteristics of this poorly studied cryptic species complex, we used comparative cytogenetic analysis of 138 individuals from 41 localities in South Siberia and Mongolia. A detailed description of the L.
View Article and Find Full Text PDFNucleosome remodeler exclusion by histone deacetylation enforces heterochromatic silencing and epigenetic inheritance.
Mol Cell
September 2024
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:
Heterochromatin enforces transcriptional gene silencing and can be epigenetically inherited, but the underlying mechanisms remain unclear. Here, we show that histone deacetylation, a conserved feature of heterochromatin domains, blocks SWI/SNF subfamily remodelers involved in chromatin unraveling, thereby stabilizing modified nucleosomes that preserve gene silencing. Histone hyperacetylation, resulting from either the loss of histone deacetylase (HDAC) activity or the direct targeting of a histone acetyltransferase to heterochromatin, permits remodeler access, leading to silencing defects.
View Article and Find Full Text PDFGenome wide inherited modifications of the tomato epigenome by trans-activated bacterial CG methyltransferase.
Cell Mol Life Sci
May 2024
INRAE, AgroParisTech, Institute Jean-Pierre Bourgin for Plant Sciences (IJPB), Université Paris-Saclay, 78000, Versailles, France.
Background: Epigenetic variation is mediated by epigenetic marks such as DNA methylation occurring in all cytosine contexts in plants. CG methylation plays a critical role in silencing transposable elements and regulating gene expression. The establishment of CG methylation occurs via the RNA-directed DNA methylation pathway and CG methylation maintenance relies on METHYLTRANSFERASE1, the homologue of the mammalian DNMT1.
View Article and Find Full Text PDFHeat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast.
Elife
January 2024
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
Eukaryotic cells are constantly exposed to various environmental stimuli. It remains largely unexplored how environmental cues bring about epigenetic fluctuations and affect heterochromatin stability. In the fission yeast , heterochromatic silencing is quite stable at pericentromeres but unstable at the mating-type () locus under chronic heat stress, although both loci are within the major constitutive heterochromatin regions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!