Here, a tumor-targeted MnO motor nanosystem (designed as MG/HA) was constructed by the assembly of glucose oxidase (GOD), manganese dioxide (MnO), and glycoprotein CD44-targeting polymer hyaluronic acid (HA) to elevate cancer-starving therapy efficacy in solid tumor. Upon the specific uptake of MG/HA by CD44 overexpressed cancer cells, GOD catalyzed the oxidation of glucose into gluconic acid and hydrogen peroxide (HO) accompanying the consumption of oxygen (O). Meanwhile, MnO would react with HO and acid to generate O, which is in turn supplied to the glucose-depletion process, running like a loop. As a result, MnO is displayed as a motor to promote the rate of glucose depletion that contributed to the starving therapy. In contrast to G/HA, MG/HA could not only achieve effective glucose consumption to depress cancer progression, but also alleviate hypoxia and reduce the expression of Glut1 to inhibit the metabolism for further restraining the tumor aggressiveness and metastasis. The concept of MnO motor shows a promising prospect to overcome the restriction of the starving therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsami.8b01818 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dual-Responsive MnO-Loaded Carbonaceous Nanobottle Motors Fabricated by Interfacial Superassembly for On-The-Fly MicroRNA Sensing.
Small
September 2024
School of Chemical Engineering & Technology, China University of Mining and Technology, Xuzhou, Jiangsu, 221116, P. R. China.
Article Synopsis
- Researchers have developed dual-responsive MnO-loaded carbonaceous nanobottle motors (MnO NBMs) that can move in response to different stimuli, enhancing motion control for various applications.* -
- These nanomotors are combined with functional nanoparticles and hairpin DNA to create swimming functional MnO NBMs for improved targeting of miRNA, which is crucial for biological sensing.* -
- The integration of these nanomotors with photoelectrochemical biosensors allows for sensitive and rapid detection of microRNA-155, demonstrating effective automation and potential for practical use in cancer diagnostics.*
Bottle Nanomotors Amplify Tumor Oxidative Stress for Enhanced Calcium Overload/Chemodynamic Therapy.
Small
November 2024
Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Article Synopsis
- Researchers developed a silicon-based nanomotor (Si-motor) loaded with manganese oxide (MnO) and calcium oxide (CaO) to improve cancer treatment by aiding drug delivery in tumors.
- The Si-motor works through a reaction in the acidic environment of tumors, generating oxygen and reactive species that enhance its movement and ability to penetrate deeper into tumors.
- This innovative approach amplifies oxidative stress in cancer cells, combining multiple mechanisms to induce higher rates of tumor cell death and offering a promising method for effective cancer therapy.
Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis.
Sci Adv
June 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR 999078, China.
Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task of mitigating excessive ROS and inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated as Motor@M2M) for targeted treatment of UC. SAM provides a protective barrier, ensuring that Motor@M2M withstands the harsh gastric milieu and exhibits controlled release.
View Article and Find Full Text PDFAccelerated and Guided Zn Diffusion via Polarized Interface Engineering Toward High Performance Wearable Zinc-Ion Batteries.
Small
October 2024
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, P. R. China.
Article Synopsis
- - Rechargeable aqueous Zn-ion batteries (ZIBs) are emerging energy storage solutions for wearable devices, but challenges like dendrite growth and uneven zinc deposition hinder performance.
- - Researchers introduced LaAlO nanoparticles to improve the interface and protect the zinc anode, enhancing zinc diffusion and overall electrochemical efficiency.
- - The developed LAO@Zn||MnO batteries achieved a notable capacity of 140 mAh g, maintaining performance over 1000 cycles, proving their practicality in powering wearable electronics like fans and wristwatches.
STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications.
J Control Release
May 2023
Department of Pharmaceutical Science, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Cyclic dinucleotides (CDNs), as one type of Stimulator of Interferon Genes (STING) pathway agonist, have shown promising results for eliciting immune responses against cancer and viral infection. However, the suboptimal drug-like properties of conventional CDNs, including their short in vivo half-life and poor cellular permeability, compromise their therapeutic efficacy. In this study, we have developed a manganese-silica nanoplatform (MnO@HMSN) that enhances the adjuvant effects of CDN by achieving synergy with Mn for vaccination against cancer and SARS-CoV-2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!