AI Article Synopsis
- Diarylethene derivatives can be manipulated by light to control their biological activity, making them potential tools for scientific research and drug development.
- There is a lack of effective examples demonstrating this photocontrol in biological systems, prompting a need for more critical analysis and understanding of the current data on these compounds.
- The article aims to highlight design principles for creating better photocontrollable diarylethene molecules, advocating for increased collaboration among pharmacologists and chemists in this area.
Article Abstract
Diarylethene derivatives, the biological activity of which can be reversibly changed by irradiation with light of different wavelengths, have shown promise as scientific tools and as candidates for photocontrollable drugs. However, examples demonstrating efficient photocontrol of their biological activity are still relatively rare. This concept article discusses the possible reasons for this situation and presents a critical analysis of existing data and hypotheses in this field, in order to extract the design principles enabling the construction of efficient photocontrollable diarylethene-based molecules. Papers addressing biologically relevant interactions between diarylethenes and biomolecules are analyzed; however, in most published cases, the efficiency of photocontrol in living systems remains to be demonstrated. We hope that this article will encourage further discussion of design principles, primarily among pharmacologists, synthetic and medicinal chemists.
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| http://dx.doi.org/10.1002/chem.201801205 | DOI Listing |
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