AI Article Synopsis
- Exercise can trigger bronchoconstriction, which is when the airways narrow, making it hard to breathe during physical activity.
- Recent studies suggest that the airway epithelium plays a crucial role in the inflammatory response that leads to this condition, involving an imbalance of inflammatory and protective substances.
- The involvement of sensory nerves and neuropeptides in exercise-induced bronchoconstriction is also being explored, but more research is needed to fully understand their role.
Article Abstract
Exercise is a common trigger of bronchoconstriction. In recent years, there has been increased understanding of the pathophysiology of exercise-induced bronchoconstriction. Although evaporative water loss and thermal changes have been recognized stimuli for exercise-induced bronchoconstriction, accumulating evidence points toward a pivotal role for the airway epithelium in orchestrating the inflammatory response linked to exercise-induced bronchoconstriction. Overproduction of inflammatory mediators, underproduction of protective lipid mediators, and infiltration of the airways with eosinophils and mast cells are all established contributors to exercise-induced bronchoconstriction. Sensory nerve activation and release of neuropeptides maybe important in exercise-induced bronchoconstriction, but further research is warranted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.iac.2018.01.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!