AI Article Synopsis
- Tributyltin is a banned antifouling agent that still appears at low levels in aquatic environments, raising concerns about its toxic effects.
- Exposure to tributyltin in adult Japanese medaka (fish) led to reduced reproduction rates and increased mortality, with high concentrations causing complete death within days.
- Early life-stage exposure showed no significant developmental issues but suppressed fish growth; however, gonadal differentiation remained unaffected, suggesting the reproduction issues may stem from toxicity rather than endocrine disruption.
Article Abstract
Tributyltin, an organotin compound, was used worldwide as an antifouling agent in aquatic environments and there has been much concern about the toxicological and ecotoxicological properties of organotin compounds. Even though it has been prohibited worldwide, tributyltin is still detected at low concentrations in aquatic environments. Here we investigated the effects of tributyltin on the early life-stage, reproduction, and gonadal sex differentiation in Japanese medaka (Oryzias latipes). In adults, exposure to tributyltin at 3.82 μg/L suppressed fecundity and fertility and increased mortality. At 10.48 μg/L all medaka died by the sixth day of exposure. Exposure to tributyltin during early life-stages induced no significant differences in mortality or embryonic development, but growth was suppressed in groups exposed to 0.13 and 0.68 μg/L. Furthermore, there was no abnormal gonadal development in Japanese medaka exposed to tributyltin. These results provide evidence of the negative effects of tributyltin on reproduction in a teleost fish. Tributyltin did not affect gonadal sex differentiation in Japanese medaka, but fecundity and fertility were suppressed, although it is not clear whether this suppression resulted from the endocrine-disrupting action of tributyltin or its toxicity.
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| http://dx.doi.org/10.1016/j.chemosphere.2018.03.135 | DOI Listing |
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