Objective: Vitamin A deficient females have reduced fertility due to decreased retinoic acid production. WIN 18,446 inhibits retinoic acid biosynthesis and functions as a contraceptive in males. We tested whether WIN 18,446 treatment would suppress fertility in female mice.
Study Design: Female mice were treated with WIN 18,446 and mated. Pregnancy rates were compared using Fisher's exact test.
Results: WIN 18,446 reduced pregnancy compared with control (p=.03). However, one animal became pregnant with malformed embryos.
Conclusions: WIN 18,446 treatment significantly reduces fecundity, but teratogenicity in the setting of contraceptive failure limits the appeal of this approach to female contraception.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174106 | PMC |
| http://dx.doi.org/10.1016/j.contraception.2018.03.035 | DOI Listing |
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