AI Article Synopsis
- Differentiating between hepatocellular carcinoma (HCC), focal nodular hyperplasia (FNH), and hepatocellular adenoma (HCA) can be challenging with atypical MRI findings, prompting a study on the effectiveness of contrast-enhanced and diffusion-weighted imaging for accurate diagnosis.
- The study involved 143 patients and utilized 1.5T MRI with volumetric assessments of lesions’ contrast enhancement and apparent diffusion coefficient (ADC) to compare the three lesion types.
- Results indicated that ADC was effective for distinguishing HCA from FNH, while arterial enhancement was the best marker for distinguishing HCC from both HCA and FNH, providing key sensitivity and specificity metrics for diagnosis.
Article Abstract
Background: Differentiating between hepatocellular carcinoma (HCC), focal nodular hyperplasia (FNH), and hepatocellular adenoma (HCA) is usually achievable by MRI. However, in some cases with atypical imaging findings accurate diagnosis may be difficult.
Purpose: To assess the diagnostic value of volumetric contrast-enhanced (CE) and volumetric diffusion-weighted imaging (DWI) in differentiating between HCC, FNH, and HCA.
Study Type: Retrospective.
Subjects: In all, 143 patients (206 lesions): 42 HCA (81 lesions), 51 FNH (65 lesions), and 50 HCC (60 lesions).
Field Strength/sequence: 1.5T MRI, T -T WI, DWI.
Assessment: Patients underwent CE-MRI and DWI (b = 0, 750 mm /s). Volumetric assessment of lesions' contrast enhancement and apparent diffusion coefficient (ADC) was performed with semiautomatic software after 3D image registration and segmentation by an observer and compared between three lesion groups. The diagnosis of lesions was based on histopathology, typical MRI findings, and/or follow-up.
Statistical Tests: Independent t-test was used to compare parameters between two groups, one-way analysis of variance (ANOVA) between three groups, and receiver operator characteristic curve (ROC) analysis to define under-curve area and optimal cutoff.
Results: Mean values (±standard deviation) for HCC, FNH, and HCA, respectively, were: 1) arterial enhancement (%), 40.5 ± 13.2, 88.6 ± 32.6, 69.6 ± 25.1; 2) venous enhancement (%) 72.4 ± 22.1, 95.2 ± 30.9, 80.7 ± 30.6; and 3) ADC (10 mm /s) 1404.5 ± 168.1, 1413.4 ± 232.1, 1070.1 ± 232.1. ADC was the best differentiator of HCA from FNH (at 1211 × 10 mm /s; sensitivity 80.4%, specificity 71.7%) and arterial enhancement was the best differentiator of HCC from both HCA (at 48%; sensitivity 80.0%, specificity 80.5%) and FNH (at 52%; sensitivity 85.7%, specificity 85.4%). A combination of arterial enhancement and ADC (at 50% and 1227 × 10 mm /s) differentiated three types of tumors with high specificity (87.9%).
Data Conclusion: Volumetric CE-MRI and volumetric DWI can help to differentiate between HCC, FNH, and HCA.
Level Of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1080-1090.
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| http://dx.doi.org/10.1002/jmri.26032 | DOI Listing |
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