AI Article Synopsis
- Five Japanese Black embryo transfer calves (30-45 days old) were examined due to reduced milk intake and low protein levels; 4 were alive and 1 was necropsied.
- The clinical evaluation revealed abnormalities such as high potassium and phosphorus levels, low protein and albumin levels, high bilirubin, and increased muscle enzyme activity.
- Necropsy of the four calves showed signs of immune complex glomerulonephritis, likely triggered by a combination of transferred antibodies at birth and subsequent vaccination against Salmonella Typhimurium.
Article Abstract
Five Japanese Black embryo transfer calves from a single embryo flush, 30 to 45-days-old, including 4 live animals for clinical examination and 1 dead for necropsy, were presented with a history of decreased milk intake and hypoproteinemia. Consistent clinicopathological abnormalities in the 4 calves presented for clinical evaluation included hyperkalemia, hyperphosphatemia, hypoproteinemia, hypoalbuminemia, hyperbilirubinemia, increased creatine phosphokinase activity, and proteinuria. Four calves ultimately were necropsied and all had histologic evidence of immune complex glomerulonephritis. Glomerulonephritis in these calves was hypothesized to have resulted from the interaction of passively acquired antibodies at birth and active immunization at 7 and 28 days of age with a Salmonella Typhimurium core antigen vaccine.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989030 | PMC |
| http://dx.doi.org/10.1292/jvms.17-0544 | DOI Listing |
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