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Emerging spp. infections in Europe: characterization of human clinical isolates from German patients.
Front Microbiol
December 2024
Department Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Bacteria of the genus are widely distributed in water bodies around the world. Some species have been identified as human pathogens causing intestinal and a variety of extraintestinal infections. In Germany, information on diseases caused by is rare, because infections are not notifiable in Germany.
View Article and Find Full Text PDFCharacterization of a novel SNP identified in Australian group A isolates derived from the M1 lineage.
mBio
December 2024
Institute for Molecular Bioscience, Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Group A (GAS) is a human-adapted pathogen responsible for a variety of diseases. The GAS M1 lineage has contributed significantly to the recently reported increases in scarlet fever and invasive infections. However, the basis for its evolutionary success is not yet fully understood.
View Article and Find Full Text PDFSynthesis of Lewis Acid-Base Adducts Between Potassium Dihydrogenpnictogenides and Group 13 Lewis Acids.
Chemistry
December 2024
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, 35043, Marburg, Germany.
Lewis acid-base adducts between potassium dihydrogenpnictogenides [K(18c6)PnH] (Pn=P, As) and Trialkylgallanes (GaMe, GaEt, GatBu) as well as BH were synthesized. In the course of these investigations, we were able to fully characterize a row of compounds of the type [K(18c6)(thf)][PnH(ER)] (E=B: R=H; E=Ga: R=Me, Et, tBu). Based on the successful syntheses of these species, we also synthesized several compounds of the composition [K(18c6)(thf)][Pn(SiMe)(ER)] (n=1, 2) starting from [KPn(SiMe)] (Pn=P and As) and ER (E=B, Al, In: R=Me; E=Ga: R=Me, Et, tBu).
View Article and Find Full Text PDFVitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers.
Front Med (Lausanne)
November 2024
Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Objectives: Vitamin D has a role in the innate immunity against pathogens and is also involved in mechanisms for reducing inflammation. VD deficiency (VDD) may increase COVID-19 infection susceptibility, however research is limited on the association between VDD and COVID-19 symptom prevalence and duration. The study aimed to determine whether VDD is a risk factor for the presence and extended duration of COVID-19 symptoms.
View Article and Find Full Text PDFThe role of asymmetric flow field-flow fractionation in drug development - From size separation to advanced characterization.
J Chromatogr A
January 2025
Coriolis Pharma Research GmbH, Fraunhoferstraße 18B, 82152 Martinsried, Germany. Electronic address:
Drug development is a complex multi-stage process that aims to deliver therapeutic products to the market. This process employs different analytical methods to separate and characterise compounds, monitor manufacturing, and validate the final drug products to ensure their safety, quality, and efficacy. However, advancements in modern drug development and discovery have led to new types of the therapeutical products of increasing complexity.
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