Differentiating positive schizotypy and mania risk scales and their associations with spontaneous eye blink rate.

Psychiatry Res

Department of Psychological Sciences, University of Missouri, Columbia, MO, United States. Electronic address:

Published: June 2018

AI Article Synopsis

  • Positive schizotypy and mania risk scales show a strong correlation (0.73), but a study indicates they are distinct factors influencing different aspects of psychopathology.
  • Researchers found that while positive schizotypy is linked to negative and disorganized schizotypy, mania risk is specifically related to self-reported manic-like episodes.
  • Interestingly, positive schizotypy correlates with a decreased spontaneous eye blink rate, whereas mania risk is associated with an increased blink rate, suggesting differing relationships with striatal dopamine.

Article Abstract

Positive schizotypy and mania risk scales are strongly correlated, and both are linked to alterations in striatal dopamine. Previous research has not examined whether these risk scales form distinct factors or whether they are differentially related to other measures of psychopathology risk or striatal dopamine. In the current study (N = 596), undergraduate students completed both positive schizotypy and mania risk scales as well as scales assessing related psychopathology (i.e., negative and disorganized schizotypy; self-reported manic-like episodes). Additionally, we measured spontaneous eye blink rate, which has been consistently associated with striatal dopamine levels. Positive schizotypy and mania risk factors were strongly correlated (factor correlation = 0.73). However, a two-factor model with positive schizotypy and mania risk as separate factors fit significantly better than a one-factor risk model. After removing shared variance, only positive schizotypy was positively associated with both negative and disorganized schizotypy, and only mania risk was related to self-reported manic-like episodes. Furthermore, positive schizotypy was associated with decreased spontaneous eye blink rate, and mania risk was associated with increased spontaneous eye blink rate. Overall, these results suggest that positive schizotypy and mania risk can be distinguished as separate factors and that they might be differentially associated with striatal dopamine measures.

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http://dx.doi.org/10.1016/j.psychres.2018.03.068DOI Listing

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