Disc dimensions and lengths of spondylophytes in the thoracolumbar junctional region (T 10-L 1) of 37 male cadaveric spines were measured from conventional radiographs. The disc degeneration was assessed by discography. The surface areas of the spondylophytes at vertebral body margins were recorded directly from the bones of 24 of the spines. Disc degeneration and the largest spondylophytes at corresponding levels measured from radiographs were related at T10-11 and at T11-12 (r = 0.41 and r = 0.43; p less than 0.01), but not at T12-L1 (r = 0.14). In the individual discs, however, only large spondylophytes in radiographs (actual length over 4 mm) were related to signs of disc degeneration. In addition, 'traction spurs' and Scheuermann's changes were more often associated with severe disc degeneration than 'claw-type' spondylophytes. The intervertebral disc space height correlated poorly with disc degeneration except, to some extent, at T11-12. Thus, the assessment of disc degeneration from conventional radiographs seems unreliable at this region of the spine.
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Animal Model Exp Med
January 2025
Department of Orthopaedic Surgery, The 909th Hospital, School of Medicine, Xiamen University, Zhangzhou, China.
Backgroud: Intervertebral disc degeneration (IDD) is one of the common degenerative diseases. Due to ethical constraints, it is difficult to obtain sufficient research on humans, so the use of an animal model of IDD is very important to clarify the pathogenesis and treatment mechanism of the disease.
Methods: In this study, thirty 2-month-old mice were selected for operation to establish a coccygeal IDD model.
Spine J
January 2025
Hoag Orthopedics, 16300 Sand Canyon Ave., Suite. 500, Irvine, CA 92618, United States. Electronic address:
Background Context: Lumbar interbody fusion (LIF) is a common surgical intervention for treating lumbar degenerative disorders. Increasing demand has contributed to ever-increasing healthcare expenditure and economic burden. To address this, cost-utility analyses (CUAs) compare value in the context of patient outcomes.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
January 2025
Massachusetts General Hospital, Department of Orthopedic Surgery. Boston, MA, USA.
Background: Painful degeneration of the sternoclavicular joint refractory to nonoperative treatment has historically been managed with resection of the degenerative segment of the medial clavicle. Although this has produced good results with improvement in symptoms, recurrent pain necessitating revision surgery is not an infrequently encountered outcome. To reduce the occurrence of recurrent postoperative pain, a novel technique to reconstruct the intra-articular disc at the time of medial clavicle resection was developed.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Polymers for Health and Biomaterials, IBMM UMR 5247, CNRS, ENSCM, University of Montpellier, 34090 Montpellier, France.
With a prevalence of over 90% in people over 50, intervertebral disc degeneration (IVDD) is a major health concern. This weakening of the intervertebral discs can lead to herniation, where the nucleus pulpus (NP) leaks through the surrounding Annulus Fibrosus (AF). Considering the limited self-healing capacity of AF tissue, an implant is needed to restore its architecture and function.
View Article and Find Full Text PDFJ Neuroophthalmol
November 2024
Ophthalmology Department (AC-C, MF-R, SA-A, RA, BS-D), Seu Maternitat, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain; Faculty of Medicine and Health Sciences (AC-C, SA-A, BS-D), Universitat de Barcelona, Barcelona, Spain; Fundació Per La Recerca Biomèdica-IDIBAPS (MF-R, SA-A, BS-D), Barcelona, Spain; and Ophthalmology Department (MS-G), Consorci Mar Parc de Salut de Barcelona, Barcelona, Spain.
Background: Autosomal Dominant Optic Atrophy (ADOA) is a hereditary optic neuropathy characterized by retinal ganglion cell degeneration and optic nerve fiber loss. This study examined the correlation between clinical and structural parameters in patients with ADOA using optical coherence tomography (OCT) and explored potential clinical biomarkers.
Methods: A cross-sectional, case-control observational study included 27 patients with ADOA and 27 age- and sex-matched healthy controls.
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