Isolation of amoenamide A and five antipodal prenylated alkaloids from NRRL 35600.

Tetrahedron Lett

Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Kumamoto, Japan.

Published: July 2017

A new prenylated alkaloid, Amoenamide A (), was isolated from the fungus NRRL 35600. Previously, was postulated to be a precursor of Notoamide E4 () converted from Notoamide E (), which was a key precursor of the prenylated indole alkaloids in the fungi of the genus . We previously succeeded in the isolation of two pairs of antipodes, Stephacidin A () and Notoamide B (), from and MF297-2 and expected the presence of other antipodes in the culture of . We here report five new antipodes () along with a new metabolite (), which was isolated as a natural compound for the first time, from .

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881583PMC
http://dx.doi.org/10.1016/j.tetlet.2017.05.057DOI Listing

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